Phenotypes associated with this allele

• Allele Symbol: Vegfb^tm1Ueks
• Allele Name: targeted mutation 1, Ulf Eriksson
• Allele ID: MGI:3609979
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vegfb^tm1Ueks/Vegfb^tm1Ueks	involves: 129P2/OlaHsd * C57BL/6	MGI:3611385

Genotype
MGI:3611385

hm1

• Allelic Composition: Vegfb^tm1Ueks/Vegfb^tm1Ueks
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:172783 )

N • animals display normal longevity

cardiovascular system

cardiovascular system phenotype ( J:172783 )

N • vasculature in dermis of hindpaw is normal in mutant animals under healthy conditions

abnormal impulse conducting system conduction ( J:103156 )

prolonged PR interval ( J:103156 )

• exhibit 10-15% increase in the time required for atrial conduction, however the QRS complex appears normal, homozygotes do not develop spontaneous arrhythmia, and serum electrolyte levels and heart development are normal

behavior/neurological

behavior/neurological phenotype ( J:172783 )

N

abnormal sensory capabilities/reflexes/nociception ( J:172783 )

• when challenged with paclitaxel treatment in the hindpaw, mutants develop a greater sensory deficit (neuropathy) than similarly treated wild-type littermates as demonstrated in a pinprick assay following high or low doses of paclitaxel

nervous system

nervous system phenotype ( J:172783 )

N • primary adult DRG neurons from adult mice show normal survival under healthy conditions in culture, but do exhibit more susceptiibity to neuronal stress than wild-type neurons in culture when exposed to paclitaxel

N • density of sensory axons in dermis of hind paws of mutants is not different from wild-type indicating that neuronal development is not affected by deficiency

neuron degeneration ( J:172783 )

• after the fourth low dose of paclitaxel, fewer sensory axons are detected in the hindpaw of mutants compared to treated wild-type, while the perfused vessel area or numbers of vascular branching points do not differ, indicating that distal degeneration of sensory nerve endings is induced by paclitaxel

reproductive system

reproductive system phenotype ( J:172783 )

N • animals are fertile