Phenotypes associated with this allele

• Allele Symbol: Otx2^{tm1(Dkk1)Imat}
• Allele Name: targeted mutation 1, Isao Matsuo
• Allele ID: MGI:3609983
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm1(Dkk1)Imat/Otx2^tm1(Dkk1)Imat	involves: C57BL/6 * CBA	MGI:3612483
cx2	Ctnnb1^tm2.1Kem/Ctnnb1^+ Otx2^tm1(Dkk1)Imat/Otx2^tm1(Dkk1)Imat	involves: 129/Sv * C57BL/6 * CBA	MGI:3612484

Genotype
MGI:3612483

hm1

• Allelic Composition: Otx2^{tm1(Dkk1)Imat}/Otx2^{tm1(Dkk1)Imat}
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal rostral-caudal axis patterning ( J:103272 )

• based on expression of anterior visceral endoderm markers, axis rotation defects observed in Otx2^tm2/Otx2^tm2 was partially rescued (n = 20/50)

• anterior neuroectoderm is not properly induced

• mutant embryos are unable to form the anterior sesendoderm properly

Genotype
MGI:3612484

cx2

• Allelic Composition: Ctnnb1^tm2.1Kem/Ctnnb1⁺; Otx2^{tm1(Dkk1)Imat}/Otx2^{tm1(Dkk1)Imat}
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

embryo

abnormal rostral-caudal axis patterning ( J:103272 )

• based on expression of anterior visceral endoderm markers, the anterior migration defects of distal visceral endoderm cells observed in 6.5 p.d.c. Otx2^tm2/Otx2^tm2 embryo was partially rescued