All Phenotypes Tg(mI56i-cre,EGFP)1Kc MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(mI56i-cre,EGFP)1Kc
transgene insertion 1, Kenneth Campbell
MGI:3609985

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Met^tm1Sst/Met^tm1Sst Tg(mI56i-cre,EGFP)1Kc/0	involves: 129P2/OlaHsd * C57BL/6J * FVB	MGI:4950068
cn2	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(mI56i-cre,EGFP)1Kc/0	involves: 129P2/OlaHsd * FVB/N	MGI:3795743
cn3	Sp8^tm2Smb/Sp8^tm2Smb Tg(mI56i-cre,EGFP)1Kc/?	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N	MGI:4837173
cn4	Slc12a2^tm1.1Jheb/Slc12a2^tm1.1Jheb Tg(mI56i-cre,EGFP)1Kc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5538344
cn5	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Tg(mI56i-cre,EGFP)1Kc/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:5569796
cn6	Arx^tm1Gldn/Arx⁺ Tg(mI56i-cre,EGFP)1Kc/0	involves: 129/Sv * C57BL/6 * CD-1 * FVB/N	MGI:3844353
cn7	Arx^tm1Gldn/Y Tg(mI56i-cre,EGFP)1Kc/0	involves: 129/Sv * C57BL/6 * CD-1 * FVB/N	MGI:3844352
cn8	Smo^tm2Amc/Smo^tm2Amc Tg(mI56i-cre,EGFP)1Kc/?	involves: 129X1/SvJ * FVB/N	MGI:3617990
cx9	Glra2^tm1.2Lngu/Glra2^tm1.2Lngu Tg(mI56i-cre,EGFP)1Kc/0	involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1	MGI:5550564
cx10	Glra2^tm1.2Lngu/Y Tg(mI56i-cre,EGFP)1Kc/0	involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1	MGI:5550563

Allelic Composition	Met^tm1Sst/Met^tm1Sst Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Met^tm1Sst mutation (1 available); any Met mutation (83 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:170554 )

• in the Morris water maze, mutants have a longer latency to locate the platform on the first 2 days of training than controls, however performance on the probe test and reversal probe test were normal, indicating normal hippocampal-mediated spatial learning

• open field activity and anxiety are not affected

abnormal learning/memory/conditioning ( J:170554 )

• on reversal discriminations, mutants require more trials than controls, indicating impaired reversal learning

impaired cued conditioning behavior ( J:170554 )

• mutants show increased latency performance on the cued-platform test, indicating a delay in striatal-dependent cued learning

nervous system

abnormal brain interneuron morphology ( J:170554 )

• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons

• distribution of striatal interneurons is altered, with fewer cells of the population located in the medial (associative) regions and more cells in the lateral (sensorimotor) areas

• reduction in the numbers of PV+ GABAergic interneurons in the primary somatosensory cortex (28% loss) and the orbitofrontal cortex (31% loss)

abnormal striatum morphology ( J:170554 )

• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons

• however, striatum appears normal

abnormal orbitofrontal cortex morphology ( J:170554 )

• 31% reduction in PV+ cells in the orbitofrontal cortex

abnormal primary somatosensory cortex morphology ( J:170554 )

• 28% loss of PV+ cells in primary somatosensory cortex

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder	DOID:0060041		J:170554
Gilles de la Tourette syndrome	DOID:11119	OMIM:137580	J:170554

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3^tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3^tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain internal capsule morphology ( J:134879 )

• the thalamocortical axons aberrantly run through the pallidum and amygdala

• while corticofugal fibers cross the pallial-subpallial boundary and enter the lateral part of the basal forebrain, they fail to progress and spiral in a disordered manner

• both corticothalamic and thalamocortial axons are abnormal

abnormal corticospinal tract morphology ( J:134879 )

Allelic Composition	Sp8^tm2Smb/Sp8^tm2Smb Tg(mI56i-cre,EGFP)1Kc/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp8^tm2Smb mutation (1 available); any Sp8 mutation (29 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:107576 )

N	• most mice do not exhibit exencephaly

abnormal olfactory bulb layer morphology ( J:107576 )

abnormal olfactory bulb external plexiform layer morphology ( J:107576 )

• reduced in size

abnormal olfactory bulb glomerular layer morphology ( J:107576 )

• stacked arrangement of glomeruli

abnormal olfactory bulb internal plexiform layer morphology ( J:107576 )

• lacking

small olfactory bulb ( J:107576 )

• noticably smaller

Allelic Composition	Slc12a2^tm1.1Jheb/Slc12a2^tm1.1Jheb Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a2^tm1.1Jheb mutation (0 available); any Slc12a2 mutation (58 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:201156 )

N	• no behavioral abnormalities are detected

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Islr2^tm2.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:210221 )

• some mice die during the fourth postnatal week

nervous system

abnormal brain morphology ( J:210221 )

• thalamic projections are misrouted into the ventral midbrain and tangled within the hypothalamus and near complete absence of corticofugal and thalamocortical axons that cross the pallial-subpallial boundary unlike in wild-type mice

abnormal telencephalon development ( J:210221 )

• at P7, pallium and subpallium are nearly completely disconnected

abnormal brain internal capsule morphology ( J:210221 )

• disorganized with partially formed rostral part of the tract

decreased corticospinal tract size ( J:210221 )

• absent at P7

Allelic Composition	Arx^tm1Gldn/Arx⁺ Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129/Sv * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arx^tm1Gldn mutation (0 available); any Arx mutation (20 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

convulsive seizures ( J:148311 )

• some adult mice develop convulsive Racine stage 5 seizures

clonic seizures ( J:148311 )

• some adult mice display epileptic spasm seizures

tonic-clonic seizures ( J:148311 )

• some adult mice display arrest of acitivity/freezing seizures

sporadic seizures ( J:148311 )

• about half of adult female mice develop spontaneous brief seizures of various types

• P14-17 mice develop seizures at a similar rate to adult females; no epileptic spasm seizures are recorded in mice at this ages

nervous system

nervous system phenotype ( J:148311 )

N	• no brain weight or gross morphological differences are detected in adult or P14-17 animals compared to controls

convulsive seizures ( J:148311 )

• some adult mice develop convulsive Racine stage 5 seizures

clonic seizures ( J:148311 )

• some adult mice display epileptic spasm seizures

tonic-clonic seizures ( J:148311 )

• some adult mice display arrest of acitivity/freezing seizures

sporadic seizures ( J:148311 )

• about half of adult female mice develop spontaneous brief seizures of various types

• P14-17 mice develop seizures at a similar rate to adult females; no epileptic spasm seizures are recorded in mice at this ages

abnormal brain interneuron morphology ( J:148311 )

• a prominent reduction in calbindin-labeled neurons in the neocortex compared to controls in the hippocampus, pattern of staining of interneurons is altered from cell body staining to mainly staining interneuron processes

• a significant reduction is observed in numbers and distribution of calretinin-labeled neurons compared to controls

abnormal brain wave pattern ( J:148311 )

• EEGs of female mice exhibit abnormal background activity; EEG is periodically interrupted by longer runs of higher amplitude, faster rhythms, and demonstrates excessive sharp activity

• females show no decrease in Delta band activity, but do exhibit an increase in faster frequency activity like male mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
early infantile epileptic encephalopathy		DOID:0050709		J:148311

Allelic Composition	Arx^tm1Gldn/Y Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129/Sv * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arx^tm1Gldn mutation (0 available); any Arx mutation (20 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:148311 )

• fewer than the expected number of male offspring are recovered from litters from crosses between cre-expressing males and Arx^tm1Gldn females

postnatal lethality, incomplete penetrance ( J:148311 )

• a siginificant number of mutant males die early in the postnatal period

behavior/neurological

clonic seizures ( J:148311 )

• some mice display seizures characterized by whole body flexion or extension movements resembling epileptic spasms

tonic-clonic seizures ( J:148311 )

• some mice display arrest of acitivity/freezing seizures

sporadic seizures ( J:148311 )

• all adult mice develop spontaneous brief seizures

• all P14-17 mice demonstrate spontaneous seizures consisting of body arching with forelimb clonus and rearing

nervous system

nervous system phenotype ( J:148311 )

N	• no brain weight or gross morphological differences are detected in adult or P14-17 animals compared to controls

clonic seizures ( J:148311 )

• some mice display seizures characterized by whole body flexion or extension movements resembling epileptic spasms

tonic-clonic seizures ( J:148311 )

• some mice display arrest of acitivity/freezing seizures

sporadic seizures ( J:148311 )

• all P14-17 mice demonstrate spontaneous seizures consisting of body arching with forelimb clonus and rearing

• all adult mice develop spontaneous brief seizures

abnormal brain interneuron morphology ( J:148311 )

• smaller reductions are observed in numbers and distribution of calretinin-labeled neurons compared to controls

abnormal brain wave pattern ( J:148311 )

• in P90-120 day-old mice, EEG is disrupted compared to controls; mice display pattern of moderate to higher amplitude and faster frequency activity

• abnormal activity is more apparent in the hippocampal rather than cortical electrodes

• adult animals show a lack of normal 4-7 Hz rhythmic theta activity while awake; hippocampal theta activity is rarely recorded, but when present has faster activity superimposed on the normal theta

• while sleeping, a lack of normal delta power and rhythmic delta activity seen in controls

• mice have a decrease in delta activity and an increase in faster frequency activity

• P14-17 animals display EEGs with slower background with lower voltage than mature controls; one animal showed infrequent large amplitude spikes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
early infantile epileptic encephalopathy		DOID:0050709		J:148311

Allelic Composition	Smo^tm2Amc/Smo^tm2Amc Tg(mI56i-cre,EGFP)1Kc/?
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smo^tm2Amc mutation (1 available); any Smo mutation (39 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:102950 )

• viable with no gross phenotype

• cortical interneuron profiles are normal

Allelic Composition	Glra2^tm1.2Lngu/Glra2^tm1.2Lngu Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra2^tm1.2Lngu mutation (0 available); any Glra2 mutation (9 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal migration ( J:202763 )

• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5

• however, only neurons traveling in the subventricular zone migratory stream

abnormal embryonic/fetal subventricular zone morphology ( J:202763 )

• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5

• however, only neurons traveling in the subventricular zone migratory stream

cellular

abnormal neuronal migration ( J:202763 )

• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5

• however, only neurons traveling in the subventricular zone migratory stream

Allelic Composition	Glra2^tm1.2Lngu/Y Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra2^tm1.2Lngu mutation (0 available); any Glra2 mutation (9 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal migration ( J:202763 )

• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5

• however, only neurons traveling in the subventricular zone migratory stream

abnormal embryonic/fetal subventricular zone morphology ( J:202763 )

• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5

• however, only neurons traveling in the subventricular zone migratory stream

cellular

abnormal neuronal migration ( J:202763 )

• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5

• however, only neurons traveling in the subventricular zone migratory stream

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