All Phenotypes Abcb1b<tm1Bor> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor Abcc2^tm1Ahs/Abcc2^tm1Ahs
Genetic Background	FVB.129P2-Abcb1b^tm1Bor Abcb1a^tm1Bor Abcc2^tm1Ahs

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1a^tm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1b^tm1Bor mutation (2 available); any Abcb1b mutation (84 available)
Abcc2^tm1Ahs mutation (0 available); any Abcc2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:107822 )

• bilary excretion of doxorubicin is reduced to about 2% normal

Allelic Composition	Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor Tg(Thy1-APPDutch)#Jckr/0
Genetic Background	FVB.Cg-Abcb1b^tm1Bor Abcb1a^tm1Bor Tg(Thy1-APPDutch)#Jckr

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:178230 )

• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

homeostasis/metabolism

amyloid beta deposits ( J:178230 )

• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

Allelic Composition	Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic Background	FVB.Cg-Abcb1b^tm1Bor Abcb1a^tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1a^tm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1b^tm1Bor mutation (2 available); any Abcb1b mutation (84 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:178230 )

• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism

amyloid beta deposits ( J:178230 )

• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased double-positive T cell number ( J:102640 )

• increase in CD4+CD8+ intestinal intraepithelial lymphocytes

decreased gamma-delta intraepithelial T cell number ( J:102640 )

• intestinal intraepithelial lymphocyte development is altered such that there is an increase in lymphocytes that express CD8alpha beta markers and a decrease in lymphocytes that express TCRgamma delta

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:102640 )

• proportion of CD8+ intestinal intraepithelial lymphocytes expressing CD8alpha beta markers rose from 5% in wild-type to 27% in mutants

abnormal T cell physiology ( J:102640 )

• proliferative responses of isolated intestinal intraepithelial lymphocytes are higher in response to PMA stimulation and lower than wild-type in response to anti-CD28 stimulation

increased interferon-gamma secretion ( J:102640 )

• PMA plus ionomycin stimulation results in increased IFN-gamma production by isolated intestinal intraepithelial lymphocytes compared to wild-type

increased interleukin-2 secretion ( J:102640 )

• isolated intestinal intraepithelial lymphocytes produce increased levels of IL-2

• PMA plus ionomycin stimulation results in increased IL-2 production by intestinal intraepithelial lymphocytes compared with wild-type while anti-CD28 stimulation results in decreased IL-2 production compared to wild-type

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:102640 , J:107822 )

• lymph node T cells and to a lesser extent, intestinal intraepithelial lymphocytes, are impaired in extruding R-123, and efflux of R-123 is not inhibited by verapamil or reserpine as in controls (J:102640)

• bilary excretion of doxorubicin reduced by about 90% (J:107822)

hematopoietic system

increased double-positive T cell number ( J:102640 )

• increase in CD4+CD8+ intestinal intraepithelial lymphocytes

decreased gamma-delta intraepithelial T cell number ( J:102640 )

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:102640 )

• proportion of CD8+ intestinal intraepithelial lymphocytes expressing CD8alpha beta markers rose from 5% in wild-type to 27% in mutants

abnormal T cell physiology ( J:102640 )

• proliferative responses of isolated intestinal intraepithelial lymphocytes are higher in response to PMA stimulation and lower than wild-type in response to anti-CD28 stimulation

Allelic Composition	Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor
Genetic Background	involves: 129P2/OlaHsd * FVB

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:39804 )

• altered pharmacokinetics of digoxin, with reduced elimination (and thus accumulation) of digoxin in the brain, adrenal glands, ovaries, and testis

• intestinal, but not biliary or urinary, excretion of digoxin is reduced in mice with a cannulated gallbladder

• intestinal, but not biliary or urinary, excretion of the anticancer drug paclitaxel is decreased compared to wild-type

• decreased rate of rhodamine efflux from hematopoietic progenitor cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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