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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Scgb1a1-cre)1Tauc
transgene insertion 1, Michael Tauc
MGI:3610310
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm1Hwu/Ptentm1Hwu
Tg(Scgb1a1-cre)1Tauc/0 		involves: 129S4/SvJae * C57BL/6 MGI:4943565
cn2
 		Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
Tg(Scgb1a1-cre)1Tauc/0 		involves: 129S4/SvJae * C57BL/6 MGI:4943568
cn3
 		Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Scgb1a1-cre)1Tauc/0 		involves: C57BL/6 MGI:5904182


Genotype
MGI:4943565
cn1
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(Scgb1a1-cre)1Tauc/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (83 available)
Tg(Scgb1a1-cre)1Tauc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:136369 )
N
• numbers of bronchioalveolar stem cells in terminal bronchi are normal




Genotype
MGI:4943568
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
Tg(Scgb1a1-cre)1Tauc/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (83 available)
Tg(Scgb1a1-cre)1Tauc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal bronchiole morphology ( J:136369 )
• bronchioles exhibit clusters of CCSP+SPC+ cells (indicators of BASCs) as early as 4 weeks of age that are not seen in controls
abnormal bronchus morphology ( J:136369 )
• mutants exhibit expansion of bronchioalveolar stem cells (BASCs) in terminal bronchi
• small bronchi exhibit clusters of CCSP+SPC+ cells (indicators of BASCs) as early as 4 weeks of age that are not seen in controls




Genotype
MGI:5904182
cn3
Allelic
Composition		 Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Scgb1a1-cre)1Tauc/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Jcbr mutation (0 available); any Igf1r mutation (85 available)
Tg(Scgb1a1-cre)1Tauc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal response to injury ( J:241923 )
• mice show a mild delay in recovery of terminal bronchiolar epithelium after naphthalene treatment to induce club cell damage, with a delay in the differentiation/regeneration of club and ciliated cells

respiratory system
abnormal bronchiole epithelium morphology ( J:241923 )
• smaller epithelial cell size in some terminal bronchioles
• lower proportion of Scgb1a1+ club cells in some terminal bronchioles




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory