All Phenotypes Tg(Scgb1a1-cre)1Tauc MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Scgb1a1-cre)1Tauc
transgene insertion 1, Michael Tauc
MGI:3610310

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm1Hwu/Pten^tm1Hwu Tg(Scgb1a1-cre)1Tauc/0	involves: 129S4/SvJae * C57BL/6	MGI:4943565
cn2	Kras^tm4Tyj/Kras⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(Scgb1a1-cre)1Tauc/0	involves: 129S4/SvJae * C57BL/6	MGI:4943568
cn3	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Tg(Scgb1a1-cre)1Tauc/0	involves: C57BL/6	MGI:5904182

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Tg(Scgb1a1-cre)1Tauc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Scgb1a1-cre)1Tauc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

respiratory system phenotype ( J:136369 )

N	• numbers of bronchioalveolar stem cells in terminal bronchi are normal

Allelic Composition	Kras^tm4Tyj/Kras⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(Scgb1a1-cre)1Tauc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Scgb1a1-cre)1Tauc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal bronchiole morphology ( J:136369 )

• bronchioles exhibit clusters of CCSP+SPC+ cells (indicators of BASCs) as early as 4 weeks of age that are not seen in controls

abnormal bronchus morphology ( J:136369 )

• mutants exhibit expansion of bronchioalveolar stem cells (BASCs) in terminal bronchi

• small bronchi exhibit clusters of CCSP+SPC+ cells (indicators of BASCs) as early as 4 weeks of age that are not seen in controls

Allelic Composition	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Tg(Scgb1a1-cre)1Tauc/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Jcbr mutation (0 available); any Igf1r mutation (88 available)
Tg(Scgb1a1-cre)1Tauc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:241923 )

• mice show a mild delay in recovery of terminal bronchiolar epithelium after naphthalene treatment to induce club cell damage, with a delay in the differentiation/regeneration of club and ciliated cells

respiratory system

abnormal bronchiole epithelium morphology ( J:241923 )

• smaller epithelial cell size in some terminal bronchioles

• lower proportion of Scgb1a1+ club cells in some terminal bronchioles

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