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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irx5tm1Hui
targeted mutation 1, Chi-chung Hui
MGI:3610374
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irx5tm1Hui/Irx5tm1Hui involves: 129S1/Sv * 129X1/SvJ MGI:3611181


Genotype
MGI:3611181
hm1
Allelic
Composition		 Irx5tm1Hui/Irx5tm1Hui
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx5tm1Hui mutation (0 available); any Irx5 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina cone bipolar cell morphology ( J:103461 )
• defects in expression of OFF cone bipolar cell specific markers suggests impaired development of type 3 OFF cone bipolar cells and impaired differentiation of type 2 OFF cone bipolar cells
narrow eye opening ( J:103461 )
• eyelid openings are smaller but gross ocular and retinal morphology are similar to wild-type

growth/size/body
decreased body size ( J:103461 )
• about 25% smaller than littermates at 3 weeks of age

nervous system
abnormal retina cone bipolar cell morphology ( J:103461 )
• defects in expression of OFF cone bipolar cell specific markers suggests impaired development of type 3 OFF cone bipolar cells and impaired differentiation of type 2 OFF cone bipolar cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory