growth/size/body
• mice are indistinguishable from and show similar growth characteristics to Prkacatm1Gsm homozygous mice
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Allele Symbol Allele Name Allele ID |
Prkacatm3Gsm targeted mutation 3, G Stanley McKnight MGI:3610390 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are indistinguishable from and show similar growth characteristics to Prkacatm1Gsm homozygous mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are 10-15% smaller than controls
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• shorter crown-anus length than controls
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• both fed and fasted/refed mutant mice show significantly lower levels of liver glycogen than controls
• fasted mice show similar levels of liver glycogen to controls
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• significant elevation consistent with decreased insulin levels
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• a decrease in serum insulin after glucose challenge occurs in contrast to an increase in control mice
• insulin clearance appears to be unaffected
• isolated pancreatic islets are defective in the ability to secrete insulin by glucose stimulation at all concentrations tested ; such islets contain more isulin than control islets, suggesting that the defect is in secretion and not in synthesis or storage
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• fasting and fed state blood glucose levels are 25% higher than controls
• mice that are fasted then refed for 6 hours exhibit normal blood glucose levels
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• fasting insulin levels are lower than controls
• slight elevation is seen after a 6 hour refeeding period
• normal insulin sensitivity is seen at two different doses of insulin
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• mutant animals exhibit an impaired ability to remove glucose from the bloodstream after intraperitoneal glucose injection
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• reductions in the levels of fructose-2,6-bisphosphate in the fed state; lower levels are thought to promote gluconeogenesis rather than glycolysis
• in the fed state, level of glucokinase transcripts are reduced; glucokinase regulates glycolysis in the liver
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• both fed and fasted/refed mutant mice show significantly lower levels of liver glycogen than controls
• fasted mice show similar levels of liver glycogen to controls
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• a decrease in serum insulin after glucose challenge occurs in contrast to an increase in control mice
• insulin clearance appears to be unaffected
• isolated pancreatic islets are defective in the ability to secrete insulin by glucose stimulation at all concentrations tested ; such islets contain more isulin than control islets, suggesting that the defect is in secretion and not in synthesis or storage
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N |
• no differences in the percent adiposity (fat pad weight by total body weight) is detected
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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