All Phenotypes Snx2<tm1Mag> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Snx2^tm1Mag
targeted mutation 1, Terry Magnuson
MGI:3610410

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snx2^tm1Mag/Snx2^tm1Mag	involves: Swiss Webster	MGI:3639297
cx2	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2^tm1Mag	involves: 129/Sv * Black Swiss * Swiss Webster	MGI:3639298
cx3	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag	involves: 129/Sv * Black Swiss * Swiss Webster	MGI:3639299
cx4	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2⁺	involves: 129/Sv * Black Swiss * Swiss Webster	MGI:3639300
cx5	Snx2^tm1Mag/Snx2^tm1Mag Vps26a^tm1Cos/Vps26a⁺	involves: 129S/SvEv	MGI:3639304
cx6	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag Vps26a^tm1Cos/Vps26a⁺	involves: 129S/SvEv	MGI:3639310
cx7	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2⁺ Vps26a^tm1Cos/Vps26a⁺	involves: 129S/SvEv	MGI:3639313
cx8	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag	Not Specified	MGI:3639314

Allelic Composition	Snx2^tm1Mag/Snx2^tm1Mag
Genetic Background	involves: Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx2^tm1Mag mutation (1 available); any Snx2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:103556 )

• homozygotes are viable and fertile and do not exhibit any overt abnormalities

Allelic Composition	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2^tm1Mag
Genetic Background	involves: 129/Sv * Black Swiss * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx1^tm1Mag mutation (1 available); any Snx1 mutation (23 available)
Snx2^tm1Mag mutation (1 available); any Snx2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:103556 )

• embryos typically arrest and die between E9.5 and E11.5

growth/size/body

decreased embryo size ( J:103556 )

• embryos are retarded in growth by E7.5

embryo

abnormal embryo turning ( J:103556 )

• in most cases, do not undergo axial rotation

caudal body truncation ( J:103556 )

• exhibit a truncated posterior at E9.5

embryonic growth arrest ( J:103556 )

• embryos typically arrest between E9.5 and E11.5

decreased embryo size ( J:103556 )

• embryos are retarded in growth by E7.5

incomplete rostral neuropore closure ( J:103556 )

• neural folds are not fused at E9.5

abnormal extraembryonic tissue morphology ( J:103556 )

• by E8.5, exhibit disproportionate growth of the extraembryonic structures compared with embryonic ectoderm, resulting in a large yolk sac and allantois compared to embryo size

abnormal visceral yolk sac morphology ( J:103556 )

• overgrowth of the yolk sac is seen at E8.5

abnormal visceral yolk sac endoderm morphology ( J:103556 )

• exhibit an increased prevalence of apical electron dense structures in the yolk sac visceral endoderm

abnormal chorioallantoic fusion ( J:103556 )

• variability in chorioallantoic fusion

nervous system

incomplete rostral neuropore closure ( J:103556 )

• neural folds are not fused at E9.5

Allelic Composition	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag
Genetic Background	involves: 129/Sv * Black Swiss * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:103556 )

• about 40% do not survive development

growth/size/body

embryonic growth retardation ( J:103556 )

• embryos are smaller and growth retarded by E11.5

decreased embryo size ( J:103556 )

• embryos are smaller by E11.5

decreased body size ( J:103556 )

• those that survive development are born runted (about 20% smaller) due to developmental growth retardation, with small size continuing into adulthood

embryo

embryonic growth retardation ( J:103556 )

• embryos are smaller and growth retarded by E11.5

decreased embryo size ( J:103556 )

• embryos are smaller by E11.5

Allelic Composition	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2⁺
Genetic Background	involves: 129/Sv * Black Swiss * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:103556 )

N	• mutants are born in expected Mendelian ratios

growth/size/body

growth/size/body region phenotype ( J:103556 )

N	• no differences in weight from single homozygous Snx1 mutants

Allelic Composition	Snx2^tm1Mag/Snx2^tm1Mag Vps26a^tm1Cos/Vps26a⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx2^tm1Mag mutation (1 available); any Snx2 mutation (43 available)
Vps26a^tm1Cos mutation (1 available); any Vps26a mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:102476 )

• 90% die during development with live embryos recovered as late as E18.5; the 10% that survive do not exhibit hemorrhage or exencephaly and are viable and fertile

cardiovascular system

hemorrhage ( J:102476 )

• embryos at E18.5 exhibit hemorrhage at different sites; occasionally seen in the head with accompanying exencephaly whereas others show blood in the abdomen

nervous system

exencephaly ( J:102476 )

• seen occasionally at E18.5

craniofacial

abnormal craniofacial morphology ( J:102476 )

• craniofacial abnormalities

Allelic Composition	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag Vps26a^tm1Cos/Vps26a⁺
Genetic Background	involves: 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:102476 )

• second wave of lethality is around E13.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:102476 )

• first wave of lethality is around E8.5

prenatal lethality, complete penetrance ( J:102476 )

• 100% die during development

growth/size/body

embryonic growth retardation ( J:102476 )

• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5

nervous system

exencephaly ( J:102476 )

• embryos that die around E13.5, exhibit exencephaly

embryo

embryonic growth retardation ( J:102476 )

• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5

Allelic Composition	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2⁺ Vps26a^tm1Cos/Vps26a⁺
Genetic Background	involves: 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:102476 )

• exhibit no lethality; born in expected Mendelian ratios

Allelic Composition	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:102476 )

• second wave of lethality is around E13.5 in 40% of embryos

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:102476 )

• first wave of lethality is around E8.5

growth/size/body

embryonic growth retardation ( J:102476 )

• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5

nervous system

exencephaly ( J:102476 )

• embryos that die around E13.5, exhibit exencephaly

embryo

embryonic growth retardation ( J:102476 )

• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5

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