All Phenotypes Snx2<tm1Mag> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Snx2^tm1Mag
targeted mutation 1, Terry Magnuson
MGI:3610410

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snx2^tm1Mag/Snx2^tm1Mag	involves: Swiss Webster	MGI:3639297
cx2	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2^tm1Mag	involves: 129/Sv * Black Swiss * Swiss Webster	MGI:3639298
cx3	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag	involves: 129/Sv * Black Swiss * Swiss Webster	MGI:3639299
cx4	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2⁺	involves: 129/Sv * Black Swiss * Swiss Webster	MGI:3639300
cx5	Snx2^tm1Mag/Snx2^tm1Mag Vps26a^tm1Cos/Vps26a⁺	involves: 129S/SvEv	MGI:3639304
cx6	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag Vps26a^tm1Cos/Vps26a⁺	involves: 129S/SvEv	MGI:3639310
cx7	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2⁺ Vps26a^tm1Cos/Vps26a⁺	involves: 129S/SvEv	MGI:3639313
cx8	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag	Not Specified	MGI:3639314

Allelic Composition	Snx2^tm1Mag/Snx2^tm1Mag
Genetic Background	involves: Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx2^tm1Mag mutation (1 available); any Snx2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:103556 )

• homozygotes are viable and fertile and do not exhibit any overt abnormalities

Allelic Composition	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2^tm1Mag
Genetic Background	involves: 129/Sv * Black Swiss * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx1^tm1Mag mutation (1 available); any Snx1 mutation (23 available)
Snx2^tm1Mag mutation (1 available); any Snx2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:103556 )

• embryos typically arrest and die between E9.5 and E11.5

growth/size/body

decreased embryo size ( J:103556 )

• embryos are retarded in growth by E7.5

embryo

abnormal embryo turning ( J:103556 )

• in most cases, do not undergo axial rotation

caudal body truncation ( J:103556 )

• exhibit a truncated posterior at E9.5

embryonic growth arrest ( J:103556 )

• embryos typically arrest between E9.5 and E11.5

decreased embryo size ( J:103556 )

• embryos are retarded in growth by E7.5

incomplete rostral neuropore closure ( J:103556 )

• neural folds are not fused at E9.5

abnormal extraembryonic tissue morphology ( J:103556 )

• by E8.5, exhibit disproportionate growth of the extraembryonic structures compared with embryonic ectoderm, resulting in a large yolk sac and allantois compared to embryo size

abnormal visceral yolk sac morphology ( J:103556 )

• overgrowth of the yolk sac is seen at E8.5

abnormal visceral yolk sac endoderm morphology ( J:103556 )

• exhibit an increased prevalence of apical electron dense structures in the yolk sac visceral endoderm

abnormal chorioallantoic fusion ( J:103556 )

• variability in chorioallantoic fusion

nervous system

incomplete rostral neuropore closure ( J:103556 )

• neural folds are not fused at E9.5

Allelic Composition	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag
Genetic Background	involves: 129/Sv * Black Swiss * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:103556 )

• about 40% do not survive development

growth/size/body

embryonic growth retardation ( J:103556 )

• embryos are smaller and growth retarded by E11.5

decreased embryo size ( J:103556 )

• embryos are smaller by E11.5

decreased body size ( J:103556 )

• those that survive development are born runted (about 20% smaller) due to developmental growth retardation, with small size continuing into adulthood

embryo

embryonic growth retardation ( J:103556 )

• embryos are smaller and growth retarded by E11.5

decreased embryo size ( J:103556 )

• embryos are smaller by E11.5

Allelic Composition	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2⁺
Genetic Background	involves: 129/Sv * Black Swiss * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:103556 )

N	• mutants are born in expected Mendelian ratios

growth/size/body

growth/size/body region phenotype ( J:103556 )

N	• no differences in weight from single homozygous Snx1 mutants

Allelic Composition	Snx2^tm1Mag/Snx2^tm1Mag Vps26a^tm1Cos/Vps26a⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx2^tm1Mag mutation (1 available); any Snx2 mutation (43 available)
Vps26a^tm1Cos mutation (1 available); any Vps26a mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:102476 )

• 90% die during development with live embryos recovered as late as E18.5; the 10% that survive do not exhibit hemorrhage or exencephaly and are viable and fertile

cardiovascular system

hemorrhage ( J:102476 )

• embryos at E18.5 exhibit hemorrhage at different sites; occasionally seen in the head with accompanying exencephaly whereas others show blood in the abdomen

nervous system

exencephaly ( J:102476 )

• seen occasionally at E18.5

craniofacial

abnormal craniofacial morphology ( J:102476 )

• craniofacial abnormalities

Allelic Composition	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag Vps26a^tm1Cos/Vps26a⁺
Genetic Background	involves: 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:102476 )

• second wave of lethality is around E13.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:102476 )

• first wave of lethality is around E8.5

prenatal lethality, complete penetrance ( J:102476 )

• 100% die during development

growth/size/body

embryonic growth retardation ( J:102476 )

• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5

nervous system

exencephaly ( J:102476 )

• embryos that die around E13.5, exhibit exencephaly

embryo

embryonic growth retardation ( J:102476 )

• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5

Allelic Composition	Snx1^tm1Mag/Snx1^tm1Mag Snx2^tm1Mag/Snx2⁺ Vps26a^tm1Cos/Vps26a⁺
Genetic Background	involves: 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:102476 )

• exhibit no lethality; born in expected Mendelian ratios

Allelic Composition	Snx1^tm1Mag/Snx1⁺ Snx2^tm1Mag/Snx2^tm1Mag
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:102476 )

• second wave of lethality is around E13.5 in 40% of embryos

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:102476 )

• first wave of lethality is around E8.5

growth/size/body

embryonic growth retardation ( J:102476 )

• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5

nervous system

exencephaly ( J:102476 )

• embryos that die around E13.5, exhibit exencephaly

embryo

embryonic growth retardation ( J:102476 )

• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24