Phenotypes associated with this allele

• Allele Symbol: Afp^{tm1(Cebpa)Ndw}
• Allele Name: targeted mutation 1, Nai-dy Wang
• Allele ID: MGI:3610508
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Afp^tm1(Cebpa)Ndw/Afp^+	involves: 129S7/SvEvBrd	MGI:3611561

Genotype
MGI:3611561

ht1

• Allelic Composition: Afp^{tm1(Cebpa)Ndw}/Afp⁺
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased liver glycogen level ( J:103404 )

• glycogen accumulation is seen earlier in fetal liver development (E15.5 and E16.5) compared to wild-type mice

decreased incidence of tumors by chemical induction ( J:103404 )

• after treatment with 10 ug/g body weight of diethylnitrosamine heterozygotes have a decreased incidence of liver tumors in every tumor size examined

• cells from induced liver tumors in heterozygotes proliferate less than cells from induced liver tumors in wild-type mice

liver/biliary system

increased liver glycogen level ( J:103404 )

• glycogen accumulation is seen earlier in fetal liver development (E15.5 and E16.5) compared to wild-type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:103404 )

• after treatment with 10 ug/g body weight of diethylnitrosamine heterozygotes have a decreased incidence of liver tumors in every tumor size examined

• cells from induced liver tumors in heterozygotes proliferate less than cells from induced liver tumors in wild-type mice