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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Angptl4tm1Akos
targeted mutation 1, Anja Koster
MGI:3610613
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Angptl4tm1Akos/Angptl4tm1Akos involves: 129P2/OlaHsd * C57BL/6 MGI:3611773
cx2
Angptl3tm1Akos/Angptl3tm1Akos
Angptl4tm1Akos/Angptl4tm1Akos
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3611775


Genotype
MGI:3611773
hm1
Allelic
Composition
Angptl4tm1Akos/Angptl4tm1Akos
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl4tm1Akos mutation (0 available); any Angptl4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in the fed state, triglyceride levels are reduced by 70% in the males but not females
• in the fasted state, triglyceride levels are reduced by 90% in males and 65% in the females
• plasma cholesterol is decreased in males but not females, in either the fed or fasted state
• postheparin plasma lipoprotein lipase activity is increased 2-fold under fed conditions and is increased 3-fold and 3.5-fold in females and males, respectively, under fasted conditions

adipose tissue
N
• no differences from wild-type in body weight or fat or lean mass




Genotype
MGI:3611775
cx2
Allelic
Composition
Angptl3tm1Akos/Angptl3tm1Akos
Angptl4tm1Akos/Angptl4tm1Akos
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl3tm1Akos mutation (0 available); any Angptl3 mutation (36 available)
Angptl4tm1Akos mutation (0 available); any Angptl4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• surviving mutants do not survive beyond 2 months of age
• more than half of the mutants exhibit pre- or perinatal mortality

growth/size/body
• surviving mutants are runted

homeostasis/metabolism
• nearly undetectable triglyceride levels





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory