All Phenotypes Angptl3<tm1Akos> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Angptl3^tm1Akos
targeted mutation 1, Anja Koster
MGI:3610614

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Angptl3^tm1Akos/Angptl3^tm1Akos	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3611772
cx2	Angptl3^tm1Akos/Angptl3^tm1Akos Angptl4^tm1Akos/Angptl4^tm1Akos	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3611775

Allelic Composition	Angptl3^tm1Akos/Angptl3^tm1Akos
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl3^tm1Akos mutation (0 available); any Angptl3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:103363 )

• plasma cholesterol is significantly lower in fed and fasted states

decreased circulating triglyceride level ( J:103363 )

• in the fed state, both males and females exhibit hypotriglyceridemia

• in the fasted state, females, but not males, exhibit hypotriglyceridemia

increased lipoprotein lipase activity ( J:103363 )

• postheparin plasma lipoprotein lipase activity is about 9-fold higher in males under fed conditions and is slightly decreased in the fasted conditions

adipose tissue

adipose tissue phenotype ( J:103363 )

N	• no differences from wild-type in body weight or fat or lean mass

Allelic Composition	Angptl3^tm1Akos/Angptl3^tm1Akos Angptl4^tm1Akos/Angptl4^tm1Akos
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl3^tm1Akos mutation (0 available); any Angptl3 mutation (36 available)
Angptl4^tm1Akos mutation (0 available); any Angptl4 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103363 )

• surviving mutants do not survive beyond 2 months of age

perinatal lethality, incomplete penetrance ( J:103363 )

• more than half of the mutants exhibit pre- or perinatal mortality

growth/size/body

decreased body size ( J:103363 )

• surviving mutants are runted

homeostasis/metabolism

decreased circulating cholesterol level ( J:103363 )

decreased circulating triglyceride level ( J:103363 )

• nearly undetectable triglyceride levels

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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