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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polqtm1Jcs
targeted mutation 1, John C Schimenti
MGI:3610670
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Polqtm1Jcs/Polqtm1Jcs involves: 129S4/SvJae * C57BL/6J MGI:3639507
cx2
 		Polntm1.2Rwd/Polntm1.2Rwd
Polqtm1Jcs/Polqtm1Jcs 		involves: 129S4/SvJae * C57BL/6J MGI:5903626


Genotype
MGI:3639507
hm1
Allelic
Composition		 Polqtm1Jcs/Polqtm1Jcs
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polqtm1Jcs mutation (1 available); any Polq mutation (127 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:103365 )
• mutants display impaired somatic hypermutation in antibodies generated after immunization with NP-CGG
• there is a decrease in all mutations in B cells in Polq-deficient mice, and the spectrum of residual somatic mutations is altered, consisting mainly of dG to dA and dT to dC transitions

hematopoietic system
abnormal somatic hypermutation frequency ( J:103365 )
• mutants display impaired somatic hypermutation in antibodies generated after immunization with NP-CGG
• there is a decrease in all mutations in B cells in Polq-deficient mice, and the spectrum of residual somatic mutations is altered, consisting mainly of dG to dA and dT to dC transitions




Genotype
MGI:5903626
cx2
Allelic
Composition		 Polntm1.2Rwd/Polntm1.2Rwd
Polqtm1Jcs/Polqtm1Jcs
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polntm1.2Rwd mutation (1 available); any Poln mutation (48 available)
Polqtm1Jcs mutation (1 available); any Polq mutation (127 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to gamma-irradiation ( J:241704 )
• in spermatids as in Polqtm1Jcs homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory