Phenotypes associated with this allele

• Allele Symbol: Gabbr2^tm1Bet
• Allele Name: targeted mutation 1, Bernhard Bettler
• Allele ID: MGI:3610995
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabbr2^tm1Bet/Gabbr2^tm1Bet	BALB/c-Gabbr2^tm1Bet	MGI:3612995
ht2	Gabbr2^tm1Bet/Gabbr2^+	BALB/c-Gabbr2^tm1Bet	MGI:3612996

Genotype
MGI:3612995

hm1

• Allelic Composition: Gabbr2^tm1Bet/Gabbr2^tm1Bet
• Genetic Background: BALB/c-Gabbr2^tm1Bet

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

clonic seizures ( J:103989 )

• several clonic type seizures are seen per day

• only clonic seizures are seen

abnormal nervous system electrophysiology ( J:103989 )

• baclofen induces an inward current in CA1 pyramidal cells instead of the outward current induced in wild-type cells

• no delta waves are seen in an EEG 20 minutes after baclofen exposure unlike in wild-type mice

abnormal brain wave pattern ( J:103989 )

• no delta waves are seen in an EEG 20 minutes after baclofen exposure unlike in wild-type mice

abnormal synaptic transmission ( J:103534 )

abnormal excitatory postsynaptic currents ( J:103989 )

• baclofen does not evoke depression of excitatory postsynaptic currents unlike in wild-type mice; however the response to adenosine is normal

abnormal inhibitory postsynaptic currents ( J:103989 )

• baclofen does not inhibit inhibitory postsynaptic currents unlike in wild-type mice; however the response to adenosine is normal

behavior/neurological

impaired behavioral response to xenobiotic ( J:103989 )

• baclofen does not impair motor coordination unlike in wild-type mice

abnormal emotion/affect behavior ( J:103989 )

impaired passive avoidance behavior ( J:103989 )

• increase in the latency to enter the dark chamber is seen during training trials compared to wild-type mice but no increase in latency is seen in retention tests unlike in wild-type mice

decreased depression-related behavior ( J:103534 )

• in a forced swim test homozygotes spend less time immobile suggesting decreased depression-related behavior

increased anxiety-related response ( J:103534 )

• a decrease in transitions between the light and dark compartments is seen with significantly less time spent in the light compartment

increased locomotor activity ( J:103989 )

• sporadic hyperlocomotor activity

• during a 1 hour observation period mice cover more distance and move at increased speed compared to wild-type mice

abnormal touch/ nociception ( J:103989 )

hyperresponsive to tactile stimuli ( J:103989 )

• reduced paw withdrawal thresholds to mechanical pressure

decreased thermal nociceptive threshold ( J:103989 )

• pronounced hyperalgesia to noxious heat is seen in the hot-plate and tail-flick tests

clonic seizures ( J:103989 )

• several clonic type seizures are seen per day

• only clonic seizures are seen

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:103989 )

• baclofen does not alter excitatory or inhibitory postsynaptic currents and induces an inward current in CA1 pyramidal cells unlike in wild-type mice

• baclofen does not induce hypothermia unlike in wild-type mice

Genotype
MGI:3612996

ht2

• Allelic Composition: Gabbr2^tm1Bet/Gabbr2⁺
• Genetic Background: BALB/c-Gabbr2^tm1Bet

behavior/neurological

abnormal emotion/affect behavior ( J:103534 )

• phenotype is stated to be similar to that of homozygotes; however no data is presented