normal phenotype
• homozygotes are fertile, have normal longevity and histological analysis of major organs failed to reveal any abnormalities
|
Allele Symbol Allele Name Allele ID |
Sphk2tm1Rlp targeted mutation 1, Richard L Proia MGI:3611080 |
||||||||||||
Summary |
2 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygotes are fertile, have normal longevity and histological analysis of major organs failed to reveal any abnormalities
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 17% of embryos are not viable at E11.5, 70% die by E12.5 and none survive past E13.5
|
• remodeling defects of blood vessels in the head are apparent at E10.5. showing the formation of enlarged, dilated blood vessels and an aberrant anastomotic network
|
• wall of the dorsal aorta is poorly developed at E11.5
|
• endothelial cells are severely defective in all blood vessels in the mesenchymal region of the head and some contain vacuoles
|
• the smooth muscle covering of the aorta is patchy and incomplete
|
• severely affected embryos exhibit widespread hemorrhaging in areas other than the brain such as the spinal cord and mandible
|
• seen in some embryos
|
• exhibit cranial hemorrhage by E11.5 and E12.5, predominately in the cranial mesenchymal region
|
• hemorrhaging in the cranial mesenchymal region is sometimes accompanied by intraventricular hemorrhages
|
• seen in some embryos
|
• the smooth muscle covering of the aorta is patchy and incomplete
|
• exhibit cranial hemorrhage by E11.5 and E12.5, predominately in the cranial mesenchymal region
|
• hemorrhaging in the cranial mesenchymal region is sometimes accompanied by intraventricular hemorrhages
|
• seen in some embryos
|
• apoptosis is increased in the neuroepithelium of the rhombencephalon
|
• apoptosis is increased in the neuroepithelium of the mesencephalon
|
• apoptosis is increased in the neuroepithelium of the mesencephalon and the rhombencephalon
|
• embryos exhibit a very thin, poorly developed wall of neuroepithelium and an irregularly shaped neuroepithelial layer in the whole brain
|
• embryos exhibit a very thin, poorly developed wall of neuroepithelium
|
• impaired anterior neural tube closure
|
• ventricular dilation at E11.5
|
• seen in 18% of embryos at E10.5, 13% at E11.5 and in 20% at E12.5, however do not observe spina bifida
|
• embryos exhibit a very thin, poorly developed wall of neuroepithelium and an irregularly shaped neuroepithelial layer in the whole brain
|
• embryos exhibit a very thin, poorly developed wall of neuroepithelium
|
• impaired anterior neural tube closure
|
• seen in some embryos
|
• apoptosis is increased in the neuroepithelium of the rhombencephalon
|
• apoptosis is increased in the neuroepithelium of the mesencephalon
|
• apoptosis is increased in the neuroepithelium of the mesencephalon and the rhombencephalon
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
![]() |
|