All Phenotypes Lama1<tm1Olf> MGI Mouse

mortality/aging ( J:160722 )

N	• normal lifespan

decreased birth weight ( J:160722 )

• 13% reduction in birth weight, but by 8 weeks of age this weight difference is no longer observed

reproductive system phenotype ( J:160722 )

N	• normal fertility

persistence of hyaloid vascular system ( J:160722 )

• the vitreal vessels remain endostatin positive throughout adulthood

macrophthalmia ( J:160722 )

• at 1 year of age eye diameters are 11% larger than those of controls

abnormal ocular fundus morphology ( J:160722 )

• ophthalmoscopy shows vitreal fibroplasia, vessel tortuosity, and retinal spots that are larger and more prominent than those in nmf223 homozygotes

abnormal retina vasculature morphology ( J:160722 )

• larger vessels lie within the vitreous and cover the entire retinal surface, and there is a lack of primary plexus veins and arteries within the retina

abnormal retina blood vessel morphology ( J:160722 )

• intermediate and deep vascular plexi are present in the retina but not as dense as those of nmf223 homozygotes

abnormal retina blood vessel pattern ( J:160722 )

abnormal Muller cell morphology ( J:160722 )

• Muller cells lacking end-feet with misguided and shortened processes are found

abnormal retina inner limiting membrane morphology ( J:160722 )

• the inner limiting membrane does not form properly

abnormal retina neuronal layer morphology ( J:160722 )

• peripheral loss of cells in the inner plexiform and both nuclear layers of the retina, which is more severe and has an earlier onset than that in nmf223 homozygotes

thin retina inner nuclear layer ( J:160722 )

thin retina inner plexiform layer ( J:160722 )

retina outer nuclear layer degeneration ( J:160722 )

retina spots ( J:160722 )

vitreal fibroplasia ( J:160722 )