Analysis Tools
mortality/aging
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• death occurs between E6.5 and E7.5
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embryo
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• increased TUNEL staining is seen in some embryos at E6.5 but not at E5.5; however, proliferation is similar to wild-type at E6.5
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• at E6.5 significantly impaired growth is seen
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• the parietal endoderm is disorganized with fewer Krt1-19 positive cells
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• Reichert's membrane is absent and maternal blood cells are seen in the yolk sac
• however, embryonic basement membrane formation is normal
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• the visceral endoderm is disorganized with fewer Gata4 positive cells
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cellular
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• increased TUNEL staining is seen in some embryos at E6.5 but not at E5.5; however, proliferation is similar to wild-type at E6.5
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growth/size/body
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• at E6.5 significantly impaired growth is seen
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