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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53Bbl
b-blast
MGI:3611496
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53Bbl/Trp53Bbl C57BL/6JSfdAnu-Trp53Bbl/Anu MGI:3611544
ht2
 		Trp53Bbl/Trp53+ C57BL/6JSfdAnu-Trp53Bbl/Anu MGI:3611545


Genotype
MGI:3611544
hm1
Allelic
Composition		 Trp53Bbl/Trp53Bbl
Genetic
Background		 C57BL/6JSfdAnu-Trp53Bbl/Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53Bbl mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leukemia incidence ( J:104190 )
• mice homozygous for this mutation develop B-cell leukemia/lymphoma or primitive hematopoietic leukemia at 4-6 months of age
increased B cell derived lymphoma incidence ( J:104190 )
• homozygous mutant mice develop B-cell leukemia, B-cell lymphoma or primitive hematopoietic leukemia at 4-6 months of age




Genotype
MGI:3611545
ht2
Allelic
Composition		 Trp53Bbl/Trp53+
Genetic
Background		 C57BL/6JSfdAnu-Trp53Bbl/Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53Bbl mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:104190 )
• between 8 and 15 months of age, mice heterozygous for this mutation develop a variety of solid tumors

endocrine/exocrine glands

nervous system

skeleton

immune system

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory