All Phenotypes Rxrb<tm1Pcn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas	MGI:3622670
cn2	Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas	MGI:3622669
cn3	Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3629395
cn4	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3629408
cn5	Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0	involves: C57BL/6 * SJL	MGI:3629396

Allelic Composition	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm1Ipc mutation (0 available); any Rxra mutation (30 available)
Rxra^tm4Ipc mutation (0 available); any Rxra mutation (30 available)
Rxrb^tm1Mma mutation (0 available); any Rxrb mutation (27 available)
Rxrb^tm1Pcn mutation (0 available); any Rxrb mutation (27 available)
Tg(KRT14-cre/ERT2)1Ipc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation

immune system

increased immunoglobulin level ( J:102470 )

• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type

integument

alopecia ( J:102470 )

• mice develop early hair loss observed around the eyes and the dorsal skin at weeks 3 to 5

hair follicle degeneration ( J:102470 )

abnormal skin morphology ( J:109090 )

• phenotype of adult mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

dermal hyperplasia ( J:102470 )

• at week 5, mice show a dense dermal hyperplasia

mixed cellular infiltration to dermis ( J:102470 )

• mutants show a weaker infiltration of the dermis

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

• with treatment with the Ppard agonist L165041, epidermis of adult mice is similar to control mice with lipids forming a continuous ribbon on top of the cornified layer

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

epidermal hyperplasia ( J:102470 )

• at week 5, mice show a dense dermal hyperplasia and hyperplasic epidermis

hematopoietic system

increased immunoglobulin level ( J:102470 )

• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop a chronic skin inflammation

immune system

enlarged spleen ( J:102470 )

• after weeks 2-8, mutants develop progressive splenomegaly

ear inflammation ( J:102470 )

• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear

increased leukocyte cell number ( J:102470 )

• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control

lymph node hyperplasia ( J:102470 )

• mutants display hyperplasia of regional lymph nodes

enlarged cervical lymph nodes ( J:102470 )

• at weeks 2 and 24, cervical lymph nodes are enlarged 2- and 10-fold respectively

dermatitis ( J:102470 )

• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions

hematopoietic system

enlarged spleen ( J:102470 )

• after weeks 2-8, mutants develop progressive splenomegaly

increased leukocyte cell number ( J:102470 )

• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control

liver/biliary system

enlarged liver ( J:102470 )

• at week 20, 50% of mutants have livers that are enlarged up to 2-fold

hearing/vestibular/ear

ear inflammation ( J:102470 )

• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear

integument

dermal cyst ( J:102470 )

dermatitis ( J:102470 )

• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions

alopecia ( J:102470 )

• mutants display progressive alopecia that is obvious by 6 weeks after Tamoxifen administration at 6 weeks of age

hair follicle degeneration ( J:102470 )

mixed cellular infiltration to dermis ( J:102470 )

• infiltrated cells and dilated blood vessels are present in the dermis; by week 24, there is heavy dermal infiltrate in mutant ears

epidermal hyperplasia ( J:102470 )

• at week 2, ear and dorsal skin biopsies show epidermal hyperplasia; at week 12. ears exhibit high epidermal hyperplasia

dry skin ( J:102470 )

• at week 6-8, mice exhibit dry skin on the trunk

scaly skin ( J:102470 )

• at week 6-8, mice exhibit scaly skin on the trunk

skin lesions ( J:102470 )

• at week 6-8, small lesions are macroscopically visible on the trunk

growth/size/body

dermal cyst ( J:102470 )

enlarged liver ( J:102470 )

• at week 20, 50% of mutants have livers that are enlarged up to 2-fold

enlarged spleen ( J:102470 )

• after weeks 2-8, mutants develop progressive splenomegaly

Allelic Composition	Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm4Ipc mutation (0 available); any Rxra mutation (30 available)
Rxrb^tm1Pcn mutation (0 available); any Rxrb mutation (27 available)
Tg(KRT14-cre)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased cholesterol level ( J:109090 )

• there is a marked decrease in cholesterol in newborns

integument

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

shiny skin ( J:109090 )

• newborns have skin with glossy appearance

Allelic Composition	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:109090 )

• phenotype of newborn mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

abnormal skin condition ( J:109090 )

• skin of newborns appears dull

Allelic Composition	Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxrb^tm1Pcn mutation (0 available); any Rxrb mutation (27 available)
Tg(KRT14-cre)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:109090 )

• no epidermal phenotype is apparent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24