All Phenotypes Rxrb<tm1Pcn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas	MGI:3622670
cn2	Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas	MGI:3622669
cn3	Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3629395
cn4	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3629408
cn5	Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0	involves: C57BL/6 * SJL	MGI:3629396

Allelic Composition	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm1Ipc mutation (0 available); any Rxra mutation (30 available)
Rxra^tm4Ipc mutation (0 available); any Rxra mutation (30 available)
Rxrb^tm1Mma mutation (0 available); any Rxrb mutation (27 available)
Rxrb^tm1Pcn mutation (0 available); any Rxrb mutation (27 available)
Tg(KRT14-cre/ERT2)1Ipc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation

immune system

increased immunoglobulin level ( J:102470 )

• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type

integument

alopecia ( J:102470 )

• mice develop early hair loss observed around the eyes and the dorsal skin at weeks 3 to 5

hair follicle degeneration ( J:102470 )

abnormal skin morphology ( J:109090 )

• phenotype of adult mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

dermal hyperplasia ( J:102470 )

• at week 5, mice show a dense dermal hyperplasia

mixed cellular infiltration to dermis ( J:102470 )

• mutants show a weaker infiltration of the dermis

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

• with treatment with the Ppard agonist L165041, epidermis of adult mice is similar to control mice with lipids forming a continuous ribbon on top of the cornified layer

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

epidermal hyperplasia ( J:102470 )

• at week 5, mice show a dense dermal hyperplasia and hyperplasic epidermis

hematopoietic system

increased immunoglobulin level ( J:102470 )

• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop a chronic skin inflammation

immune system

enlarged spleen ( J:102470 )

• after weeks 2-8, mutants develop progressive splenomegaly

ear inflammation ( J:102470 )

• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear

increased leukocyte cell number ( J:102470 )

• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control

lymph node hyperplasia ( J:102470 )

• mutants display hyperplasia of regional lymph nodes

enlarged cervical lymph nodes ( J:102470 )

• at weeks 2 and 24, cervical lymph nodes are enlarged 2- and 10-fold respectively

dermatitis ( J:102470 )

• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions

hematopoietic system

enlarged spleen ( J:102470 )

• after weeks 2-8, mutants develop progressive splenomegaly

increased leukocyte cell number ( J:102470 )

• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control

liver/biliary system

enlarged liver ( J:102470 )

• at week 20, 50% of mutants have livers that are enlarged up to 2-fold

hearing/vestibular/ear

ear inflammation ( J:102470 )

• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear

integument

dermal cyst ( J:102470 )

dermatitis ( J:102470 )

• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions

alopecia ( J:102470 )

• mutants display progressive alopecia that is obvious by 6 weeks after Tamoxifen administration at 6 weeks of age

hair follicle degeneration ( J:102470 )

mixed cellular infiltration to dermis ( J:102470 )

• infiltrated cells and dilated blood vessels are present in the dermis; by week 24, there is heavy dermal infiltrate in mutant ears

epidermal hyperplasia ( J:102470 )

• at week 2, ear and dorsal skin biopsies show epidermal hyperplasia; at week 12. ears exhibit high epidermal hyperplasia

dry skin ( J:102470 )

• at week 6-8, mice exhibit dry skin on the trunk

scaly skin ( J:102470 )

• at week 6-8, mice exhibit scaly skin on the trunk

skin lesions ( J:102470 )

• at week 6-8, small lesions are macroscopically visible on the trunk

growth/size/body

dermal cyst ( J:102470 )

enlarged liver ( J:102470 )

• at week 20, 50% of mutants have livers that are enlarged up to 2-fold

enlarged spleen ( J:102470 )

• after weeks 2-8, mutants develop progressive splenomegaly

Allelic Composition	Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm4Ipc mutation (0 available); any Rxra mutation (30 available)
Rxrb^tm1Pcn mutation (0 available); any Rxrb mutation (27 available)
Tg(KRT14-cre)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased cholesterol level ( J:109090 )

• there is a marked decrease in cholesterol in newborns

integument

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

shiny skin ( J:109090 )

• newborns have skin with glossy appearance

Allelic Composition	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:109090 )

• phenotype of newborn mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

abnormal skin condition ( J:109090 )

• skin of newborns appears dull

Allelic Composition	Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxrb^tm1Pcn mutation (0 available); any Rxrb mutation (27 available)
Tg(KRT14-cre)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:109090 )

• no epidermal phenotype is apparent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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