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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasgrf1tm4.1Pds
targeted mutation 4.1, Paul D Soloway
MGI:3611767
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Rasgrf1tm4.1Pds/Rasgrf1+ involves: 129S4/SvJaeSor * C57BL/6 MGI:3620519
cn2
 		Meox2tm1(cre)Sor/Meox2+
Rasgrf1tm4.1Pds/Rasgrf1+ 		involves: 129S4/SvJaeSor * C57BL/6 MGI:3698139
cn3
 		Rasgrf1tm4.1Pds/Rasgrf1+
Tg(Zp3-cre)3Mrt/0 		involves: 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:3698138
cn4
 		Rasgrf1tm4.1Pds/Rasgrf1+
Tg(Nes-cre)1Kln/0 		involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3698137


Genotype
MGI:3620519
ht1
Allelic
Composition		 Rasgrf1tm4.1Pds/Rasgrf1+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1tm4.1Pds mutation (0 available); any Rasgrf1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:117666 )
• DNA methylation of and Rasgrf1 expression from floxed allele are unaffected




Genotype
MGI:3698139
cn2
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Rasgrf1tm4.1Pds/Rasgrf1+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Rasgrf1tm4.1Pds mutation (0 available); any Rasgrf1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:117666 )
N
• loss of paternal repeats does not affect expression of Rasgrf1 in neonatal brain
• loss of paternal repeats at E5.5 in the epiblast does not result in changes to methylation state of the paternal allele, in contrast with deletion earlier in development




Genotype
MGI:3698138
cn3
Allelic
Composition		 Rasgrf1tm4.1Pds/Rasgrf1+
Tg(Zp3-cre)3Mrt/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1tm4.1Pds mutation (0 available); any Rasgrf1 mutation (66 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:117666 )
• Rasgrf1 expression from paternal allele is silenced in neonatal brain
abnormal imprinting ( J:117666 )
• DNA from progeny has lost almost all differentially methylated domain (DMD) methylation from the paternal allele
• methylation on floxed allele cannot be maintained upon cre-mediated recombination in zygote




Genotype
MGI:3698137
cn4
Allelic
Composition		 Rasgrf1tm4.1Pds/Rasgrf1+
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1tm4.1Pds mutation (0 available); any Rasgrf1 mutation (66 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:117666 )
N
• loss of paternal repeats does not affect expression of Rasgrf1 in neonatal brain
• loss of paternal repeats at E11 in the central nervous system does not result in changes to methylation state of the paternal allele, in contrast with deletion earlier in development




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory