About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnk3tm1Sgb
targeted mutation 1, Stephen G Brickley
MGI:3611768
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnk3tm1Sgb/Kcnk3tm1Sgb involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3620461
cx2
 		Kcnk3tm1Sgb/Kcnk3tm1Sgb
Kcnk9tm1.1Fles/Kcnk9tm1.1Fles 		B6.Cg-Kcnk3tm1Sgb Kcnk9tm1.1Fles MGI:3836807
cx3
 		Dkk3tm1Cni/Dkk3tm1Cni
Kcnk3tm1Sgb/Kcnk3tm1Sgb 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5444118


Genotype
MGI:3620461
hm1
Allelic
Composition		 Kcnk3tm1Sgb/Kcnk3tm1Sgb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk3tm1Sgb mutation (1 available); any Kcnk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal motor coordination/balance ( J:103747 )
• delayed mastering of balance on accelerating rotarod assay
• more frequent falls in narrow beam-walking test

homeostasis/metabolism
increased circulating aldosterone level ( J:188335 )
• females, but not males, have severely increased plasma aldosterone levels under basal conditions
• potassium-rich diet does not further increase plasma aldosterone levels




Genotype
MGI:3836807
cx2
Allelic
Composition		 Kcnk3tm1Sgb/Kcnk3tm1Sgb
Kcnk9tm1.1Fles/Kcnk9tm1.1Fles
Genetic
Background		 B6.Cg-Kcnk3tm1Sgb Kcnk9tm1.1Fles
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk3tm1Sgb mutation (1 available); any Kcnk3 mutation (34 available)
Kcnk9tm1.1Fles mutation (0 available); any Kcnk9 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145944 )
N
• mice exhibit normal hyperpolarization of hypothalamic neurons in response to glucose




Genotype
MGI:5444118
cx3
Allelic
Composition		 Dkk3tm1Cni/Dkk3tm1Cni
Kcnk3tm1Sgb/Kcnk3tm1Sgb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk3tm1Cni mutation (1 available); any Dkk3 mutation (28 available)
Kcnk3tm1Sgb mutation (1 available); any Kcnk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating aldosterone level ( J:188335 )
• females and males have severely increased plasma aldosterone levels under basal conditions
• potassium-rich diet does not further increase plasma aldosterone levels




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory