Phenotypes associated with this allele

• Allele Symbol: Car4^tm1Sly
• Allele Name: targeted mutation 1, William S Sly
• Allele ID: MGI:3611770
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Car4^tm1Sly/Car4^tm1Sly	involves: 129S1/Sv * C57BL/6	MGI:3620018
cx2	Car14^tm1Sly/Car14^tm1Sly Car4^tm1Sly/Car4^tm1Sly	involves: 129S1/Sv * C57BL/6	MGI:3620021

Genotype
MGI:3620018

hm1

• Allelic Composition: Car4^tm1Sly/Car4^tm1Sly
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:103742 )

• reduced survival of both male and female with a greater deficiency of females by weaning

• homozygous mice were only 38% of the number expected from Mendelian ratio

• the sex ratio was skewed in that only 31% of the homozygotes were female

• mice that survived to weaning appeared healthy, grew, and were fertile

• mating between male and female homozygous mutant mice produced small litters, and pups did not survive

Genotype
MGI:3620021

cx2

• Allelic Composition: Car14^tm1Sly/Car14^tm1Sly; Car4^tm1Sly/Car4^tm1Sly
• Genetic Background: involves: 129S1/Sv * C57BL/6

mortality/aging

postnatal lethality ( J:103742 )

• reduced survival of both male and female with a greater deficiency of females by weaning

• homozygous mice were only 38% of the number expected from Mendelian ratio

• the sex ratio was skewed in that 74% of the homozygotes were male

• male double homozygous mice that survived to weaning appeared healthy, grew, and were fertile

• many of female double homozygous mice died early

reproductive system

female infertility ( J:103742 )

♀ • few female double homozygous mice that survived to weaning were infertile

growth/size/body

decreased body size ( J:103742 )

• both males and females double homozygous mice that survived to weaning were significantly smaller than wild-type

homeostasis/metabolism

abnormal pH regulation ( J:103742 )

• blocked buffering of the alkaline pH shifts as effective as the CA inhibitor, benzolamide, that accompany neuronal activity in hippocampal slices