homeostasis/metabolism
• total cholesterol is 25% higher
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• largest portion of cholesterol increase is in the VLDL fraction
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• more than 3-fold increase in serum triglycerides in males and 2.6-fold increase in females
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• postheparin plasma lipoprotein lipase activity in males is reduced to about 6% of the level in wild-type and is undetectable in females
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adipose tissue
N |
• no differences from wild-type in lean or fat mass on chow diet or after feeding a high-fat/high-carbohydrate diet for 15 weeks
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