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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APOE-ANGPTL4)1Akos
transgene insertion 1, Anja Koster
MGI:3611784
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(APOE-ANGPTL4)1Akos/0 involves: C57BL/6 * SJL MGI:3611788


Genotype
MGI:3611788
tg1
Allelic
Composition
Tg(APOE-ANGPTL4)1Akos/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• total cholesterol is 25% higher
• largest portion of cholesterol increase is in the VLDL fraction
• more than 3-fold increase in serum triglycerides in males and 2.6-fold increase in females
• postheparin plasma lipoprotein lipase activity in males is reduced to about 6% of the level in wild-type and is undetectable in females

adipose tissue
N
• no differences from wild-type in lean or fat mass on chow diet or after feeding a high-fat/high-carbohydrate diet for 15 weeks





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory