All Phenotypes Gabra3<tm2Uru> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gabra3^tm2Uru
targeted mutation 2, Uwe Rudolph
MGI:3611843

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabra3^tm2Uru/Gabra3^tm2Uru	129X1(Cg)-Gabra3^tm2Uru	MGI:3614388
ot2	Gabra3^tm2Uru/Y	129X1(Cg)-Gabra3^tm2Uru	MGI:3614392

Allelic Composition	Gabra3^tm2Uru/Gabra3^tm2Uru
Genetic Background	129X1(Cg)-Gabra3^tm2Uru

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra3^tm2Uru mutation (1 available); any Gabra3 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased locomotor activity ( J:103831 )

• slight but significant increase in locomotor activity; however, no change in anxiety-related behavior or the anxiolytic effect of diazepam is seen in the elevated-plus-maze

nervous system

abnormal GABA-mediated receptor currents ( J:103831 )

• in midbrain dopamine neurons GABA-induced inhibitory currents are significantly reduced

decreased prepulse inhibition ( J:103831 )

• a marked decrease in prepulse inhibition is seen at all but the highest and lowest prepulse intensities; treatment with haloperidol restored prepulse inhibition to wild-type levels but ad no effect on prepulse inhibition in wild-type mice

Allelic Composition	Gabra3^tm2Uru/Y
Genetic Background	129X1(Cg)-Gabra3^tm2Uru