Analysis Tools
hematopoietic system
small thymus
(
J:104190
)
|
• the hypermutation characteristic of B and T cells is exaggerated in mutant cells during competitive reconstitution of homozygous Prkdcscid mice with mutant and wild-type cells
|
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• homozygous mutant mice have 50% the number of CD4+ cells and 25% the number of CD8+ cells as do controls
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• homozygous mutant mice have pan-lymphopenia
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• peripheral B cell counts of homozygous mutants are reduced
• spleens of homozygous mutant mice contain three-fold fewer IgM+ IgD+ cells, CD21+ IgD+ cells, or B220+ CD19+ cells than do normal control spleens
• the peritoneal cavities of homozygous mutant mice contain significantly fewer IgM+ IgD- cells and somewhat fewer IgM+ IgD+ cells than do those of normal controls
|
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• homozygous mutant mice have about four-fold fewer CD8+ cells and half as many CD4+ cells as do controls
|
|
• numbers of thymocytes at all stages of T cell maturation were diminished in homozygous mutant mice
|
immune system
small thymus
(
J:104190
)
|
• the hypermutation characteristic of B and T cells is exaggerated in mutant cells during competitive reconstitution of homozygous Prkdcscid mice with mutant and wild-type cells
|
|
• homozygous mutant mice have 50% the number of CD4+ cells and 25% the number of CD8+ cells as do controls
|
|
• homozygous mutant mice have pan-lymphopenia
|
|
• peripheral B cell counts of homozygous mutants are reduced
• spleens of homozygous mutant mice contain three-fold fewer IgM+ IgD+ cells, CD21+ IgD+ cells, or B220+ CD19+ cells than do normal control spleens
• the peritoneal cavities of homozygous mutant mice contain significantly fewer IgM+ IgD- cells and somewhat fewer IgM+ IgD+ cells than do those of normal controls
|
|
• homozygous mutant mice have about four-fold fewer CD8+ cells and half as many CD4+ cells as do controls
|
|
• numbers of thymocytes at all stages of T cell maturation were diminished in homozygous mutant mice
|
digestive/alimentary system
endocrine/exocrine glands
small thymus
(
J:104190
)
|
• numbers of thymocytes at all stages of T cell maturation were diminished in homozygous mutant mice
|
