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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kcnmb4tm1Rwa
targeted mutation 1, Richard W Aldrich
MGI:3611890
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa B6.129X1-Kcnmb4tm1Rwa MGI:3618112
hm2
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa involves: 129X1/SvJ * C57BL/6 MGI:3618110
cx3
Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa
involves: 129X1/SvJ * C57BL/6 MGI:3699110


Genotype
MGI:3618112
hm1
Allelic
Composition
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa
Genetic
Background
B6.129X1-Kcnmb4tm1Rwa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnmb4tm1Rwa mutation (0 available); any Kcnmb4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dentate gyrus granule cells in brain slice culture show a gain-of-function for BK channels that sharpens action potentials and supports higher firing rates




Genotype
MGI:3618110
hm2
Allelic
Composition
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnmb4tm1Rwa mutation (0 available); any Kcnmb4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• chronic video electroencephalogram monitoring of freely moving mice show interictal spike discharges appearing initially over the temporal cortex that spread into a fully generalized seizure episode in the neocortex
• tonic or clonic behaviors are not seen during the electrographic seizure episodes

nervous system
• chronic video electroencephalogram monitoring of freely moving mice show interictal spike discharges appearing initially over the temporal cortex that spread into a fully generalized seizure episode in the neocortex
• tonic or clonic behaviors are not seen during the electrographic seizure episodes




Genotype
MGI:3699110
cx3
Allelic
Composition
Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnmb1tm1Rwa mutation (0 available); any Kcnmb1 mutation (16 available)
Kcnmb4tm1Rwa mutation (0 available); any Kcnmb4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• at 3 weeks, double homozygotes exhibit normal subcellular localization, developmental acquisition, and expression of large conductance voltage- and calcium-activated potassium (BK) channels relative to C57BL/6 wild-type mice
• at 8 weeks, double homozygotes display normal IHC function, as shown by normal ABR thresholds in response to click or pure tone stimuli (4-, 8-, 16-, and 32 kHz) relative to C57BL/6 wild-type mice
• in addition, double homozygotes display normal OHC function, as shown by normal DPOAE magnitudes over a range of frequencies relative to C57BL/6 wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory