nervous system
• dentate gyrus granule cells in brain slice culture show a gain-of-function for BK channels that sharpens action potentials and supports higher firing rates
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Allele Symbol Allele Name Allele ID |
Kcnmb4tm1Rwa targeted mutation 1, Richard W Aldrich MGI:3611890 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• dentate gyrus granule cells in brain slice culture show a gain-of-function for BK channels that sharpens action potentials and supports higher firing rates
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• chronic video electroencephalogram monitoring of freely moving mice show interictal spike discharges appearing initially over the temporal cortex that spread into a fully generalized seizure episode in the neocortex
• tonic or clonic behaviors are not seen during the electrographic seizure episodes
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• chronic video electroencephalogram monitoring of freely moving mice show interictal spike discharges appearing initially over the temporal cortex that spread into a fully generalized seizure episode in the neocortex
• tonic or clonic behaviors are not seen during the electrographic seizure episodes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• at 3 weeks, double homozygotes exhibit normal subcellular localization, developmental acquisition, and expression of large conductance voltage- and calcium-activated potassium (BK) channels relative to C57BL/6 wild-type mice
• at 8 weeks, double homozygotes display normal IHC function, as shown by normal ABR thresholds in response to click or pure tone stimuli (4-, 8-, 16-, and 32 kHz) relative to C57BL/6 wild-type mice
• in addition, double homozygotes display normal OHC function, as shown by normal DPOAE magnitudes over a range of frequencies relative to C57BL/6 wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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