Phenotypes associated with this allele

• Allele Symbol: Stat1^fae
• Allele Name: face
• Allele ID: MGI:3611892
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stat1^fae/Stat1^fae	C57BL/6JSfdAnu-Stat1^fae/Anu	MGI:3614827

Genotype
MGI:3614827

hm1

• Allelic Composition: Stat1^fae/Stat1^fae
• Genetic Background: C57BL/6JSfdAnu-Stat1^fae/Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased IgG level ( J:105311 )

• some homozyygous mice have hypergammaglobulinemia; this occurs selectively for IgG1

abnormal T-helper 2 physiology ( J:105311 )

• all mutant mice exhibit a Th2 directed response to antigen

• all mutant mice exhibit a Th2 directed response to infection

abnormal T cell activation ( J:105311 )

• homozygous mutant mice exhibit hyperactivation of CD4⁺ and CD8⁺ T cells

hematopoietic system

increased IgG level ( J:105311 )

• some homozyygous mice have hypergammaglobulinemia; this occurs selectively for IgG1

abnormal T-helper 2 physiology ( J:105311 )

• all mutant mice exhibit a Th2 directed response to antigen

• all mutant mice exhibit a Th2 directed response to infection

abnormal T cell activation ( J:105311 )

• homozygous mutant mice exhibit hyperactivation of CD4⁺ and CD8⁺ T cells