Phenotypes associated with this allele

• Allele Symbol: Prlhr^tm1Map
• Allele Name: targeted mutation 1, Marc Parmentier
• Allele ID: MGI:3611903
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prlhr^tm1Map/Prlhr^tm1Map	involves: 129S6/SvEvTac * CD-1	MGI:3621927

Genotype
MGI:3621927

hm1

• Allelic Composition: Prlhr^tm1Map/Prlhr^tm1Map
• Genetic Background: involves: 129S6/SvEvTac * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased behavioral withdrawal response ( J:103932 )

• signs of morphine withdrawal are reduced

enhanced conditioned place preference behavior ( J:103932 )

• in a conditioned place-preference assay maximal reward behavior response to morphine is seen at 2 mg/kg rather than 6 mg/kg as in wild-type mice

abnormal mechanical nociception ( J:103932 )

• latency to withdrawal in a tail pressure test is increased in homozygotes

increased chemically-elicited antinociception ( J:103932 )

• antinociceptive effect of 10 mg/kg morphine is enhanced in a hot plate test and tail pressure test

• homozygotes develop tolerance to the antinociceptive response of morphine but the latency to develop tolerance is increased compared to wild-type mice

increased thermal nociceptive threshold ( J:103932 )

• prolonged latency in a hot plate test at 48, 50, 52, and 54 degrees C but not at 56 degrees C or in the tail immersion test

homeostasis/metabolism

decreased circulating corticosterone level ( J:103932 )

• basal corticosterone levels are slightly lower at 8 am and 4 pm

• insulin-induced hypoglycemia results in a greater difference in corticosterone levels between homozygotes and wild-type mice