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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lattm1Bpay
targeted mutation 1, B Payrastre
MGI:3611936
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lattm1Bpay/Lattm1Bpay involves: 129S2/SvPas MGI:3626183


Genotype
MGI:3626183
hm1
Allelic
Composition		 Lattm1Bpay/Lattm1Bpay
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1Bpay mutation (0 available); any Lat mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal platelet aggregation ( J:103904 )
• platelets from LAT-deficient mice aggregate normally in response to thrombin, but are no longer able to aggregate upon addition of RFY peptide at 25 micromol/l, and aggregate weakly at 50 micormol/l, showing an increase of 25% in aggregation amplitude at 100 micromol/l compared to LAT-deficient platelets stimulated by 50 micromol/l RFY
• ADP and TXA2-independent platelet aggregation induced by 50 or 100 micromol/l RFY is strongly inhibited in LAT-deficient platelets

immune system
immune system phenotype ( J:103904 )
N
• phenotype is stated to be identical to Lattm1Les; however, no data is presented in J:103904 except on platelet physiology

hematopoietic system
abnormal platelet aggregation ( J:103904 )
• platelets from LAT-deficient mice aggregate normally in response to thrombin, but are no longer able to aggregate upon addition of RFY peptide at 25 micromol/l, and aggregate weakly at 50 micormol/l, showing an increase of 25% in aggregation amplitude at 100 micromol/l compared to LAT-deficient platelets stimulated by 50 micromol/l RFY
• ADP and TXA2-independent platelet aggregation induced by 50 or 100 micromol/l RFY is strongly inhibited in LAT-deficient platelets

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory