Phenotypes associated with this allele

• Allele Symbol: Ep300^tm3Pkb
• Allele Name: targeted mutation 3, Paul K Brindle
• Allele ID: MGI:3612049
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ep300^tm3Pkb/Ep300^tm3Pkb	involves: 129S6/SvEvTac * C57BL/6	MGI:3626194
cx2	Crebbp^tm2Pkb/Crebbp^+ Ep300^tm3Pkb/Ep300^+	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:3626197
cx3	Crebbp^tm2Pkb/Crebbp^tm2Pkb Ep300^tm3Pkb/Ep300^tm3Pkb	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:3626198
cx4	Crebbp^tm2Pkb/Crebbp^+ Ep300^tm3Pkb/Ep300^tm3Pkb	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:3626199
cx5	Ep300^tm3Pkb/Ep300^+ Tg(IghMyc)22Bri/0	involves: 129S6/SvEvTac * C57BL * SJL	MGI:3626201
cx6	Ep300^tm3Pkb/Ep300^+ Tg(IghMyc)22Bri/0	involves: 129S6/SvEvTac * C57BL/6	MGI:3626202

Genotype
MGI:3626194

hm1

• Allelic Composition: Ep300^tm3Pkb/Ep300^tm3Pkb
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:103607 )

• adult homozygotes are produced at 50% of the expected frequency; at E18.5 and P0.5, homozygotes are detected at near the expected ratio

Genotype
MGI:3626197

cx2

• Allelic Composition: Crebbp^tm2Pkb/Crebbp⁺; Ep300^tm3Pkb/Ep300⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

growth/size/body

decreased body size ( J:103607 )

• compound mutants are smaller than littermates

craniofacial

abnormal craniofacial morphology ( J:103607 )

• some compound heterozygotes have craniofacial defects

Genotype
MGI:3626198

cx3

• Allelic Composition: Crebbp^tm2Pkb/Crebbp^tm2Pkb; Ep300^tm3Pkb/Ep300^tm3Pkb
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

mortality/aging

embryonic lethality during organogenesis ( J:103607 )

Genotype
MGI:3626199

cx4

• Allelic Composition: Crebbp^tm2Pkb/Crebbp⁺; Ep300^tm3Pkb/Ep300^tm3Pkb
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:103607 )

• viable embryos can be recovered at E14.5

Genotype
MGI:3626201

cx5

• Allelic Composition: Ep300^tm3Pkb/Ep300⁺; Tg(IghMyc)22Bri/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL * SJL

neoplasm

abnormal tumor susceptibility ( J:103607 )

• on a hybrid background presence of a single Ep300^tm3Pkb allele decreased the median survival time by about 8-10 weeks compared to wild-type transgenic littermates

Genotype
MGI:3626202

cx6

• Allelic Composition: Ep300^tm3Pkb/Ep300⁺; Tg(IghMyc)22Bri/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

neoplasm

abnormal tumor incidence ( J:103607 )

• on a C57BL/6 background, surivival of transgenic mutants carrying the mutant Ep300 allele were identical to that of Ep300-sufficient transgenic mice