Phenotypes associated with this allele

• Allele Symbol: Adra1d^tm1Jabl
• Allele Name: targeted mutation 1, Julie A Blendy
• Allele ID: MGI:3612161
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adra1d^tm1Jabl/Adra1d^tm1Jabl	involves: 129S6/SvEvTac	MGI:3613169

Genotype
MGI:3613169

hm1

• Allelic Composition: Adra1d^tm1Jabl/Adra1d^tm1Jabl
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:103966 )

• do not show an increase in locomotor activity following D-amphetamine administration, however response to cocaine is no different from wild-type

abnormal locomotor activation ( J:103966 )

• show a significant decrease in wheel-running activity 2 hours after onset of the dark period for a duration of 6 hours, however see no differences from wild-type in circadian rhythmicity or lcomotor activity during the subjective day, in performance in the rotarod or Morris water maze, and in cued or contextual fear conditioning

decreased vertical activity ( J:103966 )

• reduction in exploratory rearing behavior, but not ambulatory activity, in a novel cage environment