Phenotypes associated with this allele

• Allele Symbol: Rxra^pke
• Allele Name: pinkie
• Allele ID: MGI:3612274
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rxra^pke/Rxra^pke	C57BL/6J-Rxra^pke	MGI:3612280

Genotype
MGI:3612280

hm1

• Allelic Composition: Rxra^pke/Rxra^pke
• Genetic Background: C57BL/6J-Rxra^pke

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:103186 )

• the fur of homozygous mutants grays prematurely, beginning on the snout as early as 5 weeks of age, then spreading to the trunk

skeleton

kyphosis ( J:103186 )

• some mutants develop kyphosis by 1 year of age

vision/eye

cornea opacity ( J:103186 )

• with age, the eyes of homozygous mice develop a "dry" appearance and corneal opacity

hematopoietic system

abnormal T-helper 2 cell morphology ( J:103186 )

• mutant mice exhibit a more pronounced reduction with age in Th2-associated antigen-specific IgG1 production following intraperitoneal immunization with ovalbumin plus alum than do control mice

• under culture conditions favoring exclusive Th1 or mixed Th1/Th2 differentiation, purified naive mutant CD4⁺ T cells showed a much stronger Th1 bias than did those from control mice (IFNgamma⁺:IL4⁺ ratio = 309 versus 108, respectively), although under conditions favoring exclusive Th2 differentiation, the response of the mutant cells did not differ from that of wild-type cells

abnormal regulatory T cell physiology ( J:103186 )

• regulatory CD4⁺/CD25⁺ T cells (Treg) from mutant mice consistently permit greater proliferation of naive CD4⁺ T cells than do Treg from control mice, particularly and significantly when Treg from older mice are compared

immune system

abnormal T-helper 2 cell morphology ( J:103186 )

• mutant mice exhibit a more pronounced reduction with age in Th2-associated antigen-specific IgG1 production following intraperitoneal immunization with ovalbumin plus alum than do control mice

• under culture conditions favoring exclusive Th1 or mixed Th1/Th2 differentiation, purified naive mutant CD4⁺ T cells showed a much stronger Th1 bias than did those from control mice (IFNgamma⁺:IL4⁺ ratio = 309 versus 108, respectively), although under conditions favoring exclusive Th2 differentiation, the response of the mutant cells did not differ from that of wild-type cells

abnormal regulatory T cell physiology ( J:103186 )

• regulatory CD4⁺/CD25⁺ T cells (Treg) from mutant mice consistently permit greater proliferation of naive CD4⁺ T cells than do Treg from control mice, particularly and significantly when Treg from older mice are compared

abnormal dendritic cell physiology ( J:103186 )

• mutant dendritic cells consistently produce higher levels of IL-12 without stimulation, and significantly higher levels during 24 hours' stimulation with bacterial lipopolysaccharide (LPS) than do wild-type DC, despite secreting similar levles of IL-10

integument

dermal cyst ( J:103186 )

• homozygous mutants develop acne-like cysts beneath the ventral skin, which progressively become larger and more numerous; these first appear at about 8 weeks of age in females, who are generally affected earlier and more severely than males

diluted coat color ( J:103186 )

• the fur of homozygous mutants grays prematurely, beginning on the snout as early as 5 weeks of age, then spreading to the trunk

alopecia ( J:103186 )

• hair loss begins on the caudal ventrum, then spreads to the lower back, and by 4 months of age homozygous mutant mice are hairless

growth/size/body

dermal cyst ( J:103186 )

• homozygous mutants develop acne-like cysts beneath the ventral skin, which progressively become larger and more numerous; these first appear at about 8 weeks of age in females, who are generally affected earlier and more severely than males