Phenotypes associated with this allele

• Allele Symbol: Ntrk2^tm1Lfp
• Allele Name: targeted mutation 1, Luis F Parada
• Allele ID: MGI:3612277
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk2^tm1Lfp/Ntrk2^tm1Lfp	involves: 129	MGI:3612896
hm2	Ntrk2^tm1Lfp/Ntrk2^tm1Lfp	involves: 129 * C57	MGI:3612893

Genotype
MGI:3612896

hm1

• Allelic Composition: Ntrk2^tm1Lfp/Ntrk2^tm1Lfp
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal barrel cortex morphology ( J:103935 )

• delay in barrel formation through P6, but the deficiency disappears by P8

abnormal sensory neuron innervation pattern ( J:103935 )

• innervation into layer IV of the cortex by thalamic axons is uniform (rather than segregated into individual barrels) and exhibits a reduced branching within this layer compared to controls at P6, but becomes less apparent by P8

Genotype
MGI:3612893

hm2

• Allelic Composition: Ntrk2^tm1Lfp/Ntrk2^tm1Lfp
• Genetic Background: involves: 129 * C57

mortality/aging

postnatal lethality, complete penetrance ( J:104489 )

• average lifespan is 3.39 days (10 of 28 die within the first day), however those that survive past 5 days, die at an average age of 10.8 days and the maximum life span is 15 days

nervous system

abnormal somatic nervous system morphology ( J:104489 )

abnormal sensory neuron innervation pattern ( J:104489 )

• severe loss of radial fibers in the apical region of the cochlea, but less severe than in homozygous Ntrk2^tm1Bbd mice in the middle and basal turns of the cochlea

small cochlear ganglion ( J:104489 )

• 12% reduction of neuron number in cochlear ganglia

small geniculate ganglion ( J:104489 )

• 94% reduction of neuron number in geniculate ganglia

small petrosal ganglion ( J:104489 )

• 56% reduction of neuron number in nodose/petrosal ganglia

small trigeminal ganglion ( J:104489 )

• 22% reduction of neuron number in trigeminal ganglia

small nodose ganglion ( J:104489 )

• 56% reduction of neuron number in nodose/petrosal ganglia

small vestibular ganglion ( J:104489 )

• 74% reduction of neuron number in vestibular ganglia