Phenotypes associated with this allele

• Allele Symbol: Jag1^tm1.1Vtlr
• Allele Name: targeted mutation 1.1, Verdon Taylor
• Allele ID: MGI:3612395
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Jag1^tm1.1Vtlr/Jag1^+ Notch1^tm2Agt/Notch1^+	involves: 129	MGI:3618372

Genotype
MGI:3618372

cx1

• Allelic Composition: Jag1^tm1.1Vtlr/Jag1⁺; Notch1^tm2Agt/Notch1⁺
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:103728 )

• most double heterozygotes die a few hours after birth; only 10% survive up to 8 days

nervous system

abnormal rostral migratory stream morphology ( J:103728 )

• at P4, there is a significant reduction in the number of mitotic cells in the rostral migratory stream of brains from mutants at P4

abnormal postnatal subventricular zone morphology ( J:103728 )

• at P4, there is a significant reduction in the number of dividing cells in the subventricular zone of brains from double heterozygotes

• at P8, the subventricular zone is noticeably thinner, with reduced cellularity and a 60% reduction in the number of proliferating cells compared to wild-type