Phenotypes associated with this allele

• Allele Symbol: Slc4a3^tm1Cahb
• Allele Name: targeted mutation 1, Christian A Hubner
• Allele ID: MGI:3612402
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc4a3^tm1Cahb/Slc4a3^tm1Cahb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3612797

Genotype
MGI:3612797

hm1

• Allelic Composition: Slc4a3^tm1Cahb/Slc4a3^tm1Cahb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:104157 )

• bicuculline-, pentylenetetrazole- (PTZ), and pilocarpine-induced seizure latencies were decreased

• when treated with 40 mg/kg PTZ, all homozygotes displayed initial focal seizures and about 86% progressed to generalized seizures compared to wild-type mice where the occurrence was 40% and 27%, respectively

• however, no spontaneous seizures or epileptic phenotype were seen in bilateral epidural electrocorticograms

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:104157 )

• bicuculline-, pentylenetetrazole- (PTZ), and pilocarpine-induced seizure latencies were decreased

• when treated with 40 mg/kg PTZ, all homozygotes displayed initial focal seizures and about 86% progressed to generalized seizures compared to wild-type mice where the occurrence was 40% and 27%, respectively

• however, no spontaneous seizures or epileptic phenotype were seen in bilateral epidural electrocorticograms

homeostasis/metabolism

abnormal pH regulation ( J:104157 )

• hippocampal slices did not develop alkalosis when Cl- was withdrawn