Phenotypes associated with this allele

• Allele Symbol: Otx2^tm2.1Imat
• Allele Name: targeted mutation 2.1, Isao Matsuo
• Allele ID: MGI:3612403
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm2.1Imat/Otx2^tm2.1Imat	involves: C57BL/6 * CBA	MGI:3612404
ht2	Otx2^tm2.1Imat/Otx2^tm7Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:3718488

Genotype
MGI:3612404

hm1

• Allelic Composition: Otx2^tm2.1Imat/Otx2^tm2.1Imat
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal rostral-caudal axis patterning ( J:64866 )

• failure in the movement of distal visceral endoderm cells to the future anterior side

• the shift of proximal ectoderm markers to the posterior side

• axis rotation failure, resulting in a headless phenotype in 6.5 p.d.c. embryo

growth/size/body

acephaly ( J:64866 )

• headless at 6.5 p.d.c.

Genotype
MGI:3718488

ht2

• Allelic Composition: Otx2^tm2.1Imat/Otx2^tm7Sia
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

embryo

embryo phenotype ( J:91012 )

N • axis rotation occurs normally

nervous system

abnormal forebrain development ( J:91012 )

• at E12.5, forebrain defects range from mild to severe

absent midbrain ( J:91012 )

• at E12.5, in severe cases the midbrain is absent

absent forebrain ( J:91012 )

• in some cases the forebrain is absent