Phenotypes associated with this allele

• Allele Symbol: C5ar2^tm1Cge
• Allele Name: targeted mutation 1, Craig Gerard
• Allele ID: MGI:3612426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C5ar2^tm1Cge/C5ar2^tm1Cge	B6.129S1-C5ar2^tm1Cge	MGI:3617229

Genotype
MGI:3617229

hm1

• Allelic Composition: C5ar2^tm1Cge/C5ar2^tm1Cge
• Genetic Background: B6.129S1-C5ar2^tm1Cge

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune cell physiology ( J:104092 )

• cells from the bone marrow show a 30% increase in chemotaxic responsiveness to the anaphylatoxin, C5a, compared to wild-type mice

increased inflammatory response ( J:104092 )

• following pulmonary complex injury the number of total cells and neutrophils infiltrating the lung is increased 250-300% compared to wild-type mice; however no difference in the influx of monocytes is seen

• following pulmonary complex injury the concentrations of TNF and IL6 in lung homogenates and TNF levels in bronchoalveolar lavage are increased