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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mtmr2tm1Ueli
targeted mutation 1, Ueli Suter
MGI:3612427
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mtmr2tm1Ueli/Mtmr2tm1Ueli involves: 129S6/SvEvTac * C57BL/6 MGI:3613518
cx2
Mtmr2tm1Ueli/Mtmr2tm1Ueli
Sbf2Gt(XH212)Byg/Sbf2Gt(XH212)Byg
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:3784201


Genotype
MGI:3613518
hm1
Allelic
Composition
Mtmr2tm1Ueli/Mtmr2tm1Ueli
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtmr2tm1Ueli mutation (0 available); any Mtmr2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• despite myelination abnormalities, no significant differences in compound muscle action potential amplitudes, nerve conduction velocities or F-wave latencies
• in the peripheral nerves, mutant mice exhibit a variable and complex degree of myelin infoldings and outfoldings, mainly in the paranodal regions
• defects usually are associated with large caliber axons; small caliber and non-myelinated axons appear unaffected
• defects are progressive with age; rare defects are noted at 3 weeks of age and older mice at 6 months of age tend to have more affected nerve fibers

behavior/neurological
• rarely, mutant mice exhibit a mild clasping reflex when suspended by the tail
• no other siginificant motor or strength defects were detected

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease type 4B1 DOID:0110191 OMIM:601382
J:104120




Genotype
MGI:3784201
cx2
Allelic
Composition
Mtmr2tm1Ueli/Mtmr2tm1Ueli
Sbf2Gt(XH212)Byg/Sbf2Gt(XH212)Byg
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtmr2tm1Ueli mutation (0 available); any Mtmr2 mutation (38 available)
Sbf2Gt(XH212)Byg mutation (0 available); any Sbf2 mutation (105 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mild limb clamping seen starting at 2 months of age
• impaired performance on a rotarod at 12 months but not at 4 months of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory