Analysis Tools
nervous system
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• glutamate-evoked currents in GnRH neurons are inwardly rectifying, with only a tiny outward current at a test potential of +20 mV, and smaller than in controls
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behavior/neurological
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• males do not attack a wild-type male intruder and females exhibit a decrease in aggressive behavior toward male intruders during 10-min test periods compared with controls
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• in a dark-light box anxiety test, males exhibit a reduced number of exits and an increase in the latency of first exit, but spend a similar time in the lit compartment
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• females fail to retrieve pups, however nursing is normal
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• males rarely produce offspring due to decreased aggression and mounting behaviors
• males spend a similar amount of time in the middle compartment of the open field with clean bedding but significantly less time in cage bedding containing female mouse urine, however are able to sense female phermones/odorants because time spent in compartment with female bedding increased compared to time spent with clean bedding
• female bedding does not stimulate any sexual behavior in males
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• males show no interest in females and do not mount females during the night like controls
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• males show no interest in females and do not mount females during the night like controls
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reproductive system
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• although males rarely produce offspring, this is due to decreased aggression and mounting behaviors and not due to reproductive system abnormalities as testes, spermatagonia, spermatids, spermatozoa, sperm motility and serum testosterone levels are no different from controls
• females also exhibit normal ovarian morphology, litter sizes, fertility, and breeding behavior
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