All Phenotypes Zbtb33<tm1.1Bird> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zbtb33^tm1.1Bird
targeted mutation 1, Adrian Bird
MGI:3612463

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbtb33^tm1.1Bird/Zbtb33^tm1.1Bird	involves: 129P2/OlaHsd * C57BL/6	MGI:3613445
cx2	Apc^Min/Apc⁺ Zbtb33^tm1.1Bird/Y	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:3613447
ot3	Zbtb33^tm1.1Bird/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:3613444

Allelic Composition	Zbtb33^tm1.1Bird/Zbtb33^tm1.1Bird
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb33^tm1.1Bird mutation (0 available); any Zbtb33 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:104155 )

• homozygous female mice exhibit no overt phenotype and are fertile; no differences in blood cell composition are detectable

Allelic Composition	Apc^Min/Apc⁺ Zbtb33^tm1.1Bird/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Zbtb33^tm1.1Bird mutation (0 available); any Zbtb33 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:104155 )

• life span of these animals is an average of 317 days; this is improved over Apc^Min mice alone at an average of 217 days

neoplasm

increased intestinal adenoma incidence ( J:104155 )

• mice exhibit a similar number of intestinal tumors as compared to Apc^Min mice

decreased tumor growth/size ( J:104155 )

• tumors in doubly heterozygous mice significantly smaller at 180 days of age

digestive/alimentary system

increased intestinal adenoma incidence ( J:104155 )

• mice exhibit a similar number of intestinal tumors as compared to Apc^Min mice

Allelic Composition	Zbtb33^tm1.1Bird/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb33^tm1.1Bird mutation (0 available); any Zbtb33 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:104155 )

• hemizygous male mice exhibit no overt phenotype and are fertile; no differences in blood cell composition are detectable

• hemizygous ES cells exhibit no significant differences from controls in neural specificaton, viability or neuronal or glial cell differentiation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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