Phenotypes associated with this allele

• Allele Symbol: Mdm4^tm2Glo
• Allele Name: targeted mutation 2, Guillermina Lozano
• Allele ID: MGI:3612473
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0 Trp53^tm1Tyj/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * FVB/N	MGI:5907135
cn2	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0 Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:5907132
cn3	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:3616711

Genotype
MGI:5907135

cn1

• Allelic Composition: Mdm4^tm2Glo/Mdm4^tm2.1Glo; Tg(Myh6-cre)2182Mds/0; Trp53^tm1Tyj/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:137114 )

• mice die due to tumors not heart failure

extended life span ( J:137114 )

• mice show an extended mean survival of 403 days compared to compound heterozygous Mdm4^tm2Glo/Mdm4^tm2.1Glo conditional mutants

cardiovascular system

cardiovascular system phenotype ( J:137114 )

N • mice do not exhibit signs of heart failure such as edema and poor breathing and exhibit rescue of the dilated cardiomyopathy

neoplasm

increased tumor incidence ( J:137114 )

Genotype
MGI:5907132

cn2

• Allelic Composition: Mdm4^tm2Glo/Mdm4^tm2.1Glo; Tg(Myh6-cre)2182Mds/0; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N

mortality/aging

extended life span ( J:137114 )

• mice show an extended median survival of 274 days compared to compound heterozygous Mdm4^tm2Glo/Mdm4^tm2.1Glo conditional mutants

Genotype
MGI:3616711

cn3

• Allelic Composition: Mdm4^tm2Glo/Mdm4^tm2.1Glo; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N

mortality/aging

premature death ( J:104114 , J:137114 )

• some mice die within 1 year for unknown reasons, however do not observe any embryonic lethality (J:104114)

• median survival of 208 and 243 days for males and females, respectively (J:137114)

• mice die as a result of heart failure (J:137114)

cellular

increased cardiomyocyte apoptosis ( J:137114 )

cardiovascular system

cardiovascular system phenotype ( J:104114 )

N • no abnormalities in embryonic hearts are seen

decreased myocardial fiber number ( J:137114 )

• hearts exhibit half the number of cardiomyocytes at 8 months of age

increased myocardial fiber size ( J:137114 )

• marker analysis indicates cardiomyocyte hypertrophy

enlarged heart ( J:137114 )

thin ventricular wall ( J:137114 )

• ventricular walls are thinner and hypertrophic

dilated heart ventricle ( J:137114 )

• all 4 chambers are dilated and paler than control hearts

cardiac fibrosis ( J:137114 )

dilated cardiomyopathy ( J:137114 )

• severe dilated cardiomyopathy

congestive heart failure ( J:137114 )

• by 8-10 months of age, most mice have swollen bodies, have difficulty moving, and are out of breath

homeostasis/metabolism

edema ( J:137114 )

• edema in the lung and/or abdomen

muscle

decreased myocardial fiber number ( J:137114 )

• hearts exhibit half the number of cardiomyocytes at 8 months of age

increased myocardial fiber size ( J:137114 )

• marker analysis indicates cardiomyocyte hypertrophy

dilated cardiomyopathy ( J:137114 )

• severe dilated cardiomyopathy

increased cardiomyocyte apoptosis ( J:137114 )

growth/size/body

enlarged heart ( J:137114 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:137114