All Phenotypes Ahr<tm3.1Bra> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ahr^tm3.1Bra
targeted mutation 3.1, Christopher A Bradfield
MGI:3612477

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ahr^tm3.1Bra/Ahr^tm3.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	B6.Cg-Ahr^tm3.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}	MGI:3613531
cn2	Ahr^tm3.1Bra/Ahr^tm3.1Bra Tg(Tek-cre)12Flv/0	B6.Cg-Ahr^tm3.1Bra Tg(Tek-cre)12Flv	MGI:3613532
cn3	Ahr^tm3.1Bra/Ahr^tm3.1Bra Tg(Nes-cre)1Kln/0	involves: 129/Sv * C57BL/6 * SJL	MGI:6451067
cn4	Ahr^tm3.1Bra/Ahr^tm3.1Bra Tg(Six3-cre)69Frty/0	Not Specified	MGI:6199668

Allelic Composition	Ahr^tm3.1Bra/Ahr^tm3.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	B6.Cg-Ahr^tm3.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahr^tm3.1Bra mutation (1 available); any Ahr mutation (112 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:104388 )

N	• no defect in the closure of the ductus venosus is seen unlike in mice homozygous for Ahr^tm3Bra

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:104388 )

• exposure to 100 ug 2,3,7,8-tetrachlorodibenzo-p-dioxin failed to induce hepatomegaly, or Cyp1a2 expression, only weakly induced Cyp1a1 expression, partially induced Cyp1b1 expression, and resulted in significantly less liver damage compared to homozygous mice lacking the cre transgene

• however, exposure to 100 ug 2,3,7,8-tetrachlorodibenzo-p-dioxin did induce thymic involution similar to homozygous mice lacking the cre transgene

Allelic Composition	Ahr^tm3.1Bra/Ahr^tm3.1Bra Tg(Tek-cre)12Flv/0
Genetic Background	B6.Cg-Ahr^tm3.1Bra Tg(Tek-cre)12Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahr^tm3.1Bra mutation (1 available); any Ahr mutation (112 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

patent ductus venosus ( J:104388 )

• 18 of 22 mutants retain a patent ductus venosus as adults

cellular

patent ductus venosus ( J:104388 )

• 18 of 22 mutants retain a patent ductus venosus as adults

Allelic Composition	Ahr^tm3.1Bra/Ahr^tm3.1Bra Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahr^tm3.1Bra mutation (1 available); any Ahr mutation (112 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased susceptibility to ischemic brain injury ( J:292713 )

• increased proliferative neural progenitor cells (NPCs) at the ipsilesional neurogenic zones after MCAO

• decreased GFAP-positive astrogliosis and Iba1-positive microgliosis at the peri-infarct cortex after MCAO

• shorter time to remove adhesive from affected forepaws in adhesive removal test, successfully retrieved more pasta pieces in skilled reaching task and explored novel object more than familiar object in novel object recognition test for non-spatial working memory, at 48 h and 7 days after middle cerebral artery occlusion (MCAO)

abnormal glial cell morphology ( J:292713 )

• decreased GFAP-positive astrogliosis and Iba1-positive microgliosis at the peri-infarct cortex after MCAO

increased neuronal precursor cell number ( J:292713 )

• increased proliferative neural progenitor cells (NPCs) at the ipsilesional neurogenic zones after MCAO

homeostasis/metabolism

decreased susceptibility to ischemic brain injury ( J:292713 )

• increased proliferative neural progenitor cells (NPCs) at the ipsilesional neurogenic zones after MCAO

• decreased GFAP-positive astrogliosis and Iba1-positive microgliosis at the peri-infarct cortex after MCAO

Allelic Composition	Ahr^tm3.1Bra/Ahr^tm3.1Bra Tg(Six3-cre)69Frty/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahr^tm3.1Bra mutation (1 available); any Ahr mutation (112 available)
Tg(Six3-cre)69Frty mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

increased retina apoptosis ( J:265123 )

• increased expression of proapoptotic protein Ddit3

• according to TUNEL assay

short photoreceptor outer segment ( J:265123 )

• thinner at age 18 months

photoreceptor outer segment degeneration ( J:265123 )

• thinner at age 18 months

retina photoreceptor degeneration ( J:265123 )

• reduced number of photoreceptor cells per row in outer nuclear layer (ONL) at age 18 months

retina outer nuclear layer degeneration ( J:265123 )

• reduced number of photoreceptor cells per row at age 18 months

retina degeneration ( J:265123 )

• reduced number of photoreceptor cells outer nuclear layer (ONL) per row at age 18 months

• thinner outer segment at age 18 months

• inner nuclear layer (INL) at age 18 months

abnormal rod electrophysiology ( J:265123 )

• decreased scotopic responses at age 12 months: around 30 % reduction in b-wave and around 15 % reduction in a-wave mean amplitude at 0 and 1 log cd.s/m² light intensity

nervous system

short photoreceptor outer segment ( J:265123 )

• thinner at age 18 months

photoreceptor outer segment degeneration ( J:265123 )

• thinner at age 18 months

retina photoreceptor degeneration ( J:265123 )

• reduced number of photoreceptor cells per row in outer nuclear layer (ONL) at age 18 months

cellular

increased retina apoptosis ( J:265123 )

• increased expression of proapoptotic protein Ddit3

• according to TUNEL assay

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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