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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mylk2tm1Jtst
targeted mutation 1, James T Stull
MGI:3612478
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mylk2tm1Jtst/Mylk2tm1Jtst involves: 129S6/SvEvTac * C57BL/6 MGI:3617226


Genotype
MGI:3617226
hm1
Allelic
Composition
Mylk2tm1Jtst/Mylk2tm1Jtst
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylk2tm1Jtst mutation (0 available); any Mylk2 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• in extensor digitorum longus muscle at 10 s after a tetanic stimulation (150 Hz for 2 s) no increase in twitch tension is seen, unlike in wild-type mice where a 75% increase is seen
• in extensor digitorum longus muscle following repetitive stimulation at a constant low frequency the initial transient decrease is present but during the recovery phase the maximum tension increase is only 30% compared to 55% in wild-type
• in both cases phosphorylation of regulatory light chain myosin is decreased compared to wild-type; however phosphorylation in cardiac myocytes is normal
• no other obvious abnormalities are seen in homozygous mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory