All Phenotypes Wnt3a<tm2Eag> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt3a^tm2Eag
targeted mutation 2, Elizabeth A Grove
MGI:3612796

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Emx1^tm1(cre)Krj/Emx1⁺ Wnt3a^tm2Eag/Wnt3a⁺	involves: 129S2/SvPas	MGI:3616432
cn2	Tg(Otx1-cre)1Eag/0 Wnt3a^tm2Eag/Wnt3a⁺	Not Specified	MGI:3616434

Allelic Composition	Emx1^tm1(cre)Krj/Emx1⁺ Wnt3a^tm2Eag/Wnt3a⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Wnt3a^tm2Eag mutation (0 available); any Wnt3a mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:104373 )

• mice die shortly after birth

craniofacial

short mandible ( J:104373 )

• lower jaw is shorter than normal

nervous system

absent Cajal-Retzius cell ( J:104373 )

• at E12.5, the neocortical zone shows a near complete absence of Cajal-Retzius cells

• at !3.5 and 15.5. the band of Cajal-Retzius cells along the marginal zone of the cortex is absent

absent choroid plexus ( J:104373 )

• at E12.5, the choroid plexus is almost completely absent

abnormal cerebral cortex morphology ( J:104373 )

• at E10, the cortical hem is almost completely ablated

• the caudomedial cortex is highly disorganized and shrunken; however, at E18.5, the layers of the rostral cortex are correctly ordered

skeleton

short mandible ( J:104373 )

• lower jaw is shorter than normal

behavior/neurological

abnormal suckling behavior ( J:104373 )

• newborn mice are unable to suckle

Allelic Composition	Tg(Otx1-cre)1Eag/0 Wnt3a^tm2Eag/Wnt3a⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Otx1-cre)1Eag mutation (0 available)
Wnt3a^tm2Eag mutation (0 available); any Wnt3a mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:104373 )

• numbers of Cajal-Retzius cells in neocortical layer are greatly reduced and remaining cells are dispersed

decreased Cajal-Retzius cell number ( J:104373 )

• numbers of Cajal-Retzius cells in neocortical layer are greatly reduced

abnormal cerebral cortex morphology ( J:104373 )

• cortical hem is present, but smaller than normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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