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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Limk2whe
white eyes
MGI:3612836
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Limk2whe/Limk2whe B6.Cg-Lepob Limk2whe/GrsrJ MGI:3762585


Genotype
MGI:3762585
hm1
Allelic
Composition
Limk2whe/Limk2whe
Genetic
Background
B6.Cg-Lepob Limk2whe/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Limk2whe mutation (1 available); any Limk2 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• atypical growth of blood vessels on the cornea
• corneal inflammation seen by histological analysis
• inner canthal distance is significantly larger in homozygous females
• at 2 days of age the eyelids are either completely or partially open

craniofacial
• female, but not male, homozygotes have a shorter mandible than sex-matched heterozygous controls

immune system
• corneal inflammation seen by histological analysis

skeleton
N
• bone mineral density and bone mineral content are normal
• female, but not male, homozygotes have a shorter mandible than sex-matched heterozygous controls

hearing/vestibular/ear
N
• ABR analysis of 2 homozygotes at 3 months of age indicates normal hearing

adipose tissue
N
• body composition of percent lean and percent fat are normal

cardiovascular system
• atypical growth of blood vessels on the cornea





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory