Phenotypes associated with this allele

• Allele Symbol: nmf391
• Allele Name: neuroscience mutagenesis facility, 391
• Allele ID: MGI:3612864
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	nmf391/nmf391	C57BL/6J-nmf391/J	MGI:3612865

Genotype
MGI:3612865

hm1

• Allelic Composition: nmf391/nmf391
• Genetic Background: C57BL/6J-nmf391/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:87349 )

• homozygous mutants exhibit body tremors from about 6.8 weeks of age

myoclonus ( J:87349 )

• from about 6.8 weeks of age, mutant mice experience brief spasms of the hind limbs manifesting as rapid, intermittent contractions and extensions

growth/size/body

decreased body size ( J:87349 )

hearing/vestibular/ear

ear inflammation ( J:87349 )

• standard pathology examination revealed otitis in three of four mutants ages 87 - 177 days

immune system

ear inflammation ( J:87349 )

• standard pathology examination revealed otitis in three of four mutants ages 87 - 177 days

muscle

myoclonus ( J:87349 )

• from about 6.8 weeks of age, mutant mice experience brief spasms of the hind limbs manifesting as rapid, intermittent contractions and extensions

dystrophic muscle ( J:87349 )

• standard pathology examination of four mutants ages 87 - 177 days revealed mild muscular dystrophy in two mice, ages 94 and 177 days

muscle weakness ( J:87349 )

• homozygous mutant mice from approximately 6.8 weeks of age exhibit splaying of the hind legs

nervous system

myoclonus ( J:87349 )

• from about 6.8 weeks of age, mutant mice experience brief spasms of the hind limbs manifesting as rapid, intermittent contractions and extensions