Analysis Tools
behavior/neurological
limb grasping
(
J:87349
)
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• upon being lifted by their tails, mutants keep their hind legs close, and their torsos flex backward
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• from about 3.7 weeks of age, homozygous mutant mice exhibit a tottering gait with swaying of the torso
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• hind legs of mutant mice from about 3.7 weeks of age are held close to their bodies and appear to have limited movement capacity
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head tossing
(
J:87349
)
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• from about 3.7 weeks of age, homozygous mutants exhibit intense head tossing
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muscle
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• standard pathology examination of the hind limb muscles of three mice aged 77, 78 and 110 days revealed regions occupied by very small muscle fibers
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• standard pathology examination revealed neurogenic myopathy of the hind limbs, with replacement of muscle by fat, in three older mice (ages 77, 78 and 110 days) examined; no abnormalities were seen in muscles of two 20 day old mice
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nervous system
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• standard pathology examination revealed loss of granule cells in the cerebella of the three older mice (ages 77, 78 and 110 days) examined; no abnormalities were seen in two 20 day old mice
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• standard pathology examination revealed vacuolation of the ventral spinal cord roots in a single mouse, of 4 examined, older than 76 days
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• standard pathology examination revealed degenerating nerve fibers in hind limb muscles of three mice aged 77, 78 and 110 days
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