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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdx4tm1.1Jdes
targeted mutation 1.1, Jacqueline Deschamps
MGI:3612959
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cdx1tm1Pgr/Cdx1tm1Pgr
Cdx4tm1.1Jdes/Y 		involves: 129 * C57BL/6 * CBA * FVB MGI:3613764
cx2
 		Cdx2tm1Fbe/Cdx2+
Cdx4tm1.1Jdes/Y 		involves: 129 * C57BL/6 * CBA * FVB MGI:3613767
cx3
 		Cdx2tm1Fbe/Cdx2+
Cdx4tm1.1Jdes/Cdx4+ 		involves: 129 * C57BL/6 * CBA * FVB MGI:3613771
ot4
 		Cdx4tm1.1Jdes/Y involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB MGI:3613762


Genotype
MGI:3613764
cx1
Allelic
Composition		 Cdx1tm1Pgr/Cdx1tm1Pgr
Cdx4tm1.1Jdes/Y
Genetic
Background		 involves: 129 * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)
Cdx4tm1.1Jdes mutation (0 available); any Cdx4 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased rib number ( J:104372 )
• thoracic to cervical transformation of V8, with the consequent loss of one rib
thoracic vertebral transformation ( J:104372 )
• 5 of 7 have their first rib on the 9th vertebrae (V9) instead of on V8 (thoracic to cervical transformation of V8, with the consequent loss of one rib), with 3 of 5 exhibiting this transformation bilaterally
• 5 of 7 have the 8th rib pair attached to the sternum bilaterally, indicating anterior transformation at the level of V15




Genotype
MGI:3613767
cx2
Allelic
Composition		 Cdx2tm1Fbe/Cdx2+
Cdx4tm1.1Jdes/Y
Genetic
Background		 involves: 129 * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx2tm1Fbe mutation (0 available); any Cdx2 mutation (22 available)
Cdx4tm1.1Jdes mutation (0 available); any Cdx4 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
embryonic growth retardation ( J:104372 )
• exhibit developmental retardation at E10.5

embryo
sirenomelia ( J:104372 )
• truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud
embryonic growth retardation ( J:104372 )
• exhibit developmental retardation at E10.5
abnormal allantois morphology ( J:104372 )
• allantoic endothelial cells often exhibit, to a variable extent, a poorer degree of primary vessel organization around the time of chorioallantoic fusion
abnormal placenta vasculature ( J:104372 )
• at E10.5, maternal blood pools and embryonic blood vessels are widely separated
absent placenta hemotrichorial membrane ( J:104372 )
• the hemotrichorial membrane is almost completely absent
abnormal placenta labyrinth morphology ( J:104372 )
• all embryos that do undergo chorioallantoic fusion display deficient placental labyrinth development at E10.5
• fail to properly extend the allantoic vascular network into the chorionic ectoderm and do not develop a functional placental labyrinth
failure of chorioallantoic fusion ( J:104372 )
• allantois of 7 of 35 mutants has not fused with the chorion at E9.5

skeleton
increased rib number ( J:104372 )
• have 14 ribs due to the partial or complete bilateral rib attachment to V21
thoracic vertebral transformation ( J:104372 )
• 4 of 4 have the 8th pair of ribs attached to the sternum, indicating anterior transformation at the level of V15
lumbar vertebral transformation ( J:104372 )
• 4 of 4 have a partial or complete rib attached to V21 bilaterally, at the position normally corresponding to the first lumbar vertebrae

homeostasis/metabolism
edema ( J:104372 )
• thoracic edema at E10.5

limbs/digits/tail
sirenomelia ( J:104372 )
• truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud

cardiovascular system
abnormal placenta vasculature ( J:104372 )
• at E10.5, maternal blood pools and embryonic blood vessels are widely separated




Genotype
MGI:3613771
cx3
Allelic
Composition		 Cdx2tm1Fbe/Cdx2+
Cdx4tm1.1Jdes/Cdx4+
Genetic
Background		 involves: 129 * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx2tm1Fbe mutation (0 available); any Cdx2 mutation (22 available)
Cdx4tm1.1Jdes mutation (0 available); any Cdx4 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal placenta labyrinth morphology ( J:104372 )
• 2 of 11 embryos that do undergo normal chorioallantoic fusion display deficient placental labyrinth development at E10.5
failure of chorioallantoic fusion ( J:104372 )
• allantois of 2 of 28 mutants has not fused with the chorion at E9.5




Genotype
MGI:3613762
ot4
Allelic
Composition		 Cdx4tm1.1Jdes/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx4tm1.1Jdes mutation (0 available); any Cdx4 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
thoracic vertebral transformation ( J:104372 )
• 1 of 8 have the eighth rib pair attached to the sternum, indicating a very mild anterior transformation at the level of V15 with extremely low penetrance, otherwise mice are healthy and appear normal




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory