All Phenotypes Sim1<tm1Jlmd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sim1^tm1Jlmd/Sim1^tm1Jlmd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3613783
cx2	Sim1^tm1Jlmd/Sim1^tm1Jlmd Sim2^tm1Fan/Sim2^tm1Fan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3613784
cx3	Sim1^tm1Fan/Sim1^tm1Jlmd Sim2^tm1Fan/Sim2^tm1Fan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3613785

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:104419 )

nervous system

nervous system phenotype ( J:120909 )

N	• PVN/SON progenitors are generated and differentiate normally in mutant mice

abnormal neuronal migration ( J:120909 )

• by E12.5, a subtle but noticeable difference in the shape of the paraventricular nucleus/supraoptic nucleus (PVN/SON) progenitor domains is observed between mutants and controls

• at E13.5, mutant cells are never found at the lateral pia surface

• at E14.5 when normal PVN and SON neurons are distinguishable in controls, mutant cells are less coherent and stay as a scattered group of cells between normal PVN and SON positions

• at E15.5, mutant cells remain mislocalized

• at P0, no mutant cells are found at normal PVN or SON positions

abnormal hypothalamus morphology ( J:104419 , J:120909 )

• severe defects of the paraventricular, supraoptic and anterior paraventricular nuclei are seen (J:104419)

• a slight dorsal shift of the hypothalamic Dlx1 domain is observed (J:120909)

abnormal nervous system tract morphology ( J:104419 )

• at E18.5, the principal mammillary axonal tract appears less prominent and contains additional axons originating laterally, which project towards the midline and become splayed

cellular

decreased apoptosis ( J:120909 )

• between E14.5 and E16.5, there are less apoptotic cells in the presumptive paraventricular nucleus (PVN) area in mutants than in heterozygous controls

abnormal neuronal migration ( J:120909 )

• by E12.5, a subtle but noticeable difference in the shape of the paraventricular nucleus/supraoptic nucleus (PVN/SON) progenitor domains is observed between mutants and controls

• at E13.5, mutant cells are never found at the lateral pia surface

• at E14.5 when normal PVN and SON neurons are distinguishable in controls, mutant cells are less coherent and stay as a scattered group of cells between normal PVN and SON positions

• at E15.5, mutant cells remain mislocalized

• at P0, no mutant cells are found at normal PVN or SON positions

Allelic Composition	Sim1^tm1Jlmd/Sim1^tm1Jlmd Sim2^tm1Fan/Sim2^tm1Fan
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1^tm1Jlmd mutation (0 available); any Sim1 mutation (52 available)
Sim2^tm1Fan mutation (0 available); any Sim2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system tract morphology ( J:104419 )

• at E18.5, the principal mammillary axonal tract and mammilothalmic tract are absent

• on the mammillary body in the location of the principal mammillary axonal tract a group of ectopic axons is seen and at the most posterior level of the mammillary body these axons cross the midline ventrocaudally to the third ventricle

Allelic Composition	Sim1^tm1Fan/Sim1^tm1Jlmd Sim2^tm1Fan/Sim2^tm1Fan
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1^tm1Fan mutation (0 available); any Sim1 mutation (52 available)
Sim1^tm1Jlmd mutation (0 available); any Sim1 mutation (52 available)
Sim2^tm1Fan mutation (0 available); any Sim2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:104419 )

• at E11.5 mammillary body axon bundles are not detectable

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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