Phenotypes associated with this allele

• Allele Symbol: TgTn(sb-T2/Onc)68Dla
• Allele Name: transgenic transposon concatemer 68, David A Largaespada
• Allele ID: MGI:3612984
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(sb11)Njen/Gt(ROSA)26Sor^+ Trp53^tm3Tyj/Trp53^+ Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+ TgTn(sb-T2/Onc)68Dla/0	involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N	MGI:3839859
cn2	Gt(ROSA)26Sor^tm2(sb11)Njen/Gt(ROSA)26Sor^+ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)68Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839797
cn3	Gt(ROSA)26Sor^tm2(sb11)Njen/Gt(ROSA)26Sor^+ Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+ TgTn(sb-T2/Onc)68Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839857
cx4	Sclt1^Tg(CAG-sb10)1Dla/0 TgTn(sb-T2/Onc)68Dla/0	FVB/N-TgTn(sb-T2/Onc)68Dla Sclt1^Tg(CAG-sb10)1Dla	MGI:3613026
cx5	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Sclt1^Tg(CAG-sb10)1Dla/0 TgTn(sb-T2/Onc)68Dla/0	involves: 129X1/SvJ * FVB/N	MGI:3613024

Genotype
MGI:3839859

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺; Trp53^tm3Tyj/Trp53⁺; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺; TgTn(sb-T2/Onc)68Dla/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

liver/biliary system

abnormal liver morphology ( J:147264 )

• preneoplastic nodules are first detected at about 160 days of age in males

• liver nodules in quadruple transgenic mice are larger and more numerous compared to triple transgenic mice that are wild-type at the Trp53 locus

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

Genotype
MGI:3839797

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺; Tg(Vil1-cre)20Syr/0; TgTn(sb-T2/Onc)68Dla/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

mortality/aging

premature death ( J:146887 )

neoplasm

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

Genotype
MGI:3839857

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺; TgTn(sb-T2/Onc)68Dla/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

neoplasm

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

liver/biliary system

abnormal liver morphology ( J:147264 )

• preneoplastic nodules are first detected at about 160 days of age in males

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

Genotype
MGI:3613026

cx4

• Allelic Composition: Sclt1^{Tg(CAG-sb10)1Dla}/0; TgTn(sb-T2/Onc)68Dla/0
• Genetic Background: FVB/N-TgTn(sb-T2/Onc)68Dla Sclt1^{Tg(CAG-sb10)1Dla}

neoplasm

neoplasm ( J:99991 )

N • up to 1 year of age no signs of increased tumor susceptibility are seen

Genotype
MGI:3613024

cx5

• Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs; Sclt1^{Tg(CAG-sb10)1Dla}/0; TgTn(sb-T2/Onc)68Dla/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

mortality/aging

premature death ( J:99991 )

• mice died earlier than those homozygous for Cdkn2a^tm1Cjs alone

neoplasm

increased tumor incidence ( J:99991 )

• tumor spectrum was similar to Cdkn2a^tm1Cjs homozygotes and included malignant meningiomas

increased leukemia incidence ( J:99991 )

• myeloid leukemias were seen

increased lymphoma incidence ( J:99991 )

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

increased sarcoma incidence ( J:99991 )

• soft tissue sarcomas or osteosarcomas

increased osteosarcoma incidence ( J:99991 )

respiratory system

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

skeleton

increased osteosarcoma incidence ( J:99991 )