Phenotypes associated with this allele

• Allele Symbol: TgTn(sb-T2/Onc)76Dla
• Allele Name: transgenic transposon concatemer 76, David A Largaespada
• Allele ID: MGI:3612986
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Etv6^tm1.1(RUNX1,hsb5)Lvdw/Etv6^+ TgTn(sb-T2/Onc)76Dla/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N	MGI:5284841
cn2	Gt(ROSA)26Sor^tm2(sb11)Njen/Gt(ROSA)26Sor^+ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)76Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839798
cx3	Sclt1^Tg(CAG-sb10)1Dla/0 TgTn(sb-T2/Onc)76Dla/0	FVB/N-TgTn(sb-T2/Onc)76Dla Sclt1^Tg(CAG-sb10)1Dla	MGI:3613025
cx4	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Sclt1^Tg(CAG-sb10)1Dla/0 TgTn(sb-T2/Onc)76Dla/0	involves: 129X1/SvJ * FVB/N	MGI:3613023

Genotype
MGI:5284841

cn1

• Allelic Composition: Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺; TgTn(sb-T2/Onc)76Dla/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174866 )

• mice exhibit increased decreased survival compared with control mice

neoplasm

increased leukemia incidence ( J:174866 )

• mice exhibit increased incidence of leukemia compared with control mice

• predominantly acute myeloid leukemia (AML; 46%) with some T cell acute lymphocytic leukemia (T-ALL; 28%) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL; 21%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:174866

Genotype
MGI:3839798

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺; Tg(Vil1-cre)20Syr/0; TgTn(sb-T2/Onc)76Dla/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

mortality/aging

premature death ( J:146887 )

neoplasm

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

Genotype
MGI:3613025

cx3

• Allelic Composition: Sclt1^{Tg(CAG-sb10)1Dla}/0; TgTn(sb-T2/Onc)76Dla/0
• Genetic Background: FVB/N-TgTn(sb-T2/Onc)76Dla Sclt1^{Tg(CAG-sb10)1Dla}

neoplasm

neoplasm ( J:99991 )

N • up to 1 year of age no signs of increased tumor susceptibility are seen

Genotype
MGI:3613023

cx4

• Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs; Sclt1^{Tg(CAG-sb10)1Dla}/0; TgTn(sb-T2/Onc)76Dla/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

mortality/aging

premature death ( J:99991 )

• mice died earlier than those homozygous for Cdkn2a^tm1Cjs alone

neoplasm

increased tumor incidence ( J:99991 )

• tumor spectrum was similar to Cdkn2a^tm1Cjs homozygotes and included malignant meningiomas

increased leukemia incidence ( J:99991 )

• myeloid leukemias were seen

increased lymphoma incidence ( J:99991 )

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

increased sarcoma incidence ( J:99991 )

• soft tissue sarcomas or osteosarcomas

increased osteosarcoma incidence ( J:99991 )

respiratory system

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

skeleton

increased osteosarcoma incidence ( J:99991 )